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eosinophil differentiation

Known as: eosinophil cell differentiation 
The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil. [GOC:add, GOC:mah]
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone‐dependent severe asthma
In severe asthmatics with persistent airway eosinophilia, blockade of interleukin‐5 has significant steroid‐sparing effects and… 
Highly Cited
2015
Highly Cited
2015
The transcription factor XBP1 is selectively required for eosinophil differentiation
The transcription factor XBP1 has been linked to the development of highly secretory tissues such as plasma cells and Paneth… 
Highly Cited
2000
Highly Cited
2000
Evidence for Local Eosinophil Differentiation Within Allergic Nasal Mucosa: Inhibition with Soluble IL-5 Receptor1
Eosinophil differentiation occurs within the bone marrow in response to eosinopoietic cytokines, particularly IL-5. Recently… 
Highly Cited
1998
Highly Cited
1998
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.
Hematopoietic differentiation involves the commitment of multipotent progenitors to a given lineage, followed by the maturation… 
Highly Cited
1990
Highly Cited
1990
Eosinophilia in transgenic mice expressing interleukin 5
Experiments in vitro suggest that although interleukin 5 (IL-5) stimulates the late stages of eosinophil differentiation, other… 
Highly Cited
1990
Highly Cited
1990
Regulatory effect of cytokines on eosinophil degranulation.
We tested the effects of different cytokines on IgA- and IgG-induced eosinophil degranulation in vitro to determine the potential… 
Highly Cited
1989
Highly Cited
1989
Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF.
Recombinant human interleukin-5 (rhIL-5), in either liquid or semi-solid cultures, selectively induced eosinophil production from… 
Highly Cited
1987
Highly Cited
1987
Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).
The human eosinophil differentiation factor (EDF) gene was cloned from a genomic library in lambda phage EMBL3A by using a murine… 
Highly Cited
1986
Highly Cited
1986
Murine eosinophil differentiation factor. An eosinophil-specific colony- stimulating factor with activity for human cells
A purified murine lymphokine, eosinophil differentiation factor (EDF), was found to be a selective stimulus for the clonal… 
Highly Cited
1985
Highly Cited
1985
Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures
Factors stimulating eosinophil differentiation in vitro have been studied by means of a liquid bone marrow culture system in… 
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