entacapone

Known as: Entacaponum, N,N-Diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide, (E)-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)-N,N-diethyl-prop-2-enamide 
A nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
OBJECTIVE L-dopa is the most widely used and most effective therapy for Parkinson disease (PD), but chronic treatment is… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Rasagiline mesylate is a novel drug for Parkinson's disease with selective, irreversible monoamine oxidase B (MAO-B… (More)
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Review
2005
Review
2005
BACKGROUND The development of fluctuations in motor response and involuntary movements commonly complicate the treatment of… (More)
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Highly Cited
2005
Highly Cited
2005
Long-acting dopamine agonist drugs induce a lower incidence of dyskinesia in MPTP-treated primates and patients with Parkinson's… (More)
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Highly Cited
2004
Highly Cited
2004
Several plant species defend themselves indirectly from herbivores by producing herbivore-induced volatile compounds that attract… (More)
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2004
2004
A levodopa/carbidopa/entacapone combination product (Stalevo) was recently approved to treat patients with idiopathic Parkinson's… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE To study the effect and safety of entacapone as an adjunct to levodopa treatment in patients with PD with wearing-off… (More)
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Highly Cited
1997
Highly Cited
1997
  • Annals of neurology
  • 1997
Motor fluctuations associated with levodopa therapy are common problems encountered in the long-term treatment of Parkinson's… (More)
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Highly Cited
1995
Highly Cited
1995
Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at… (More)
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1994
1994
We studied the effect of entacapone, a selective catechol-O-methyltransferase inhibitor, on the bioavailability and clinical… (More)
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