endonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. [GOC:mah, ISBN:0198547684]
National Institutes of Health

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2015
2015
During Cas9 genome editing in eukaryotic cells, the bacterial Cas9 enzyme cleaves DNA targets within chromatin. To understand how… (More)
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2011
Highly Cited
2011
Piwi proteins and Piwi-interacting RNAs (piRNAs) have conserved functions in transposon silencing. The murine Piwi proteins Mili… (More)
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2009
Highly Cited
2009
Nuclear and cytoplasmic forms of the yeast exosome share 10 components, of which only Rrp44/Dis3 is believed to possess 3… (More)
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2009
2009
The influenza A RNA polymerase possesses endonuclease activity to digest the host mRNA. Thus this endonuclease domain can be a… (More)
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2006
Highly Cited
2006
The Artemis nuclease is defective in radiosensitive severe combined immunodeficiency patients and is required for the repair of a… (More)
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2006
Highly Cited
2006
The RNA-dependent RNA polymerase of influenza virus is a heterotrimer formed by the PB1, PB2, and PA subunits. Although PA is… (More)
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2001
Highly Cited
2001
Apurinic/apyrimidinic endonuclease (Ap endo) is a key DNA repair activity that confers resistance to ionizing radiation and… (More)
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2000
2000
Abasic (apurinic/apyrimidinic; AP) sites are generated in vivo through spontaneous base loss and by enzymatic removal of bases… (More)
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1994
Highly Cited
1994
Influenza virus polymerase complexes that were expressed in the absence of genomic viral RNA and nucleoprotein were examined for… (More)
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1991
Highly Cited
1991
Past studies have shown that serum-free cultures of PC12 cells are a useful model system for studying the neuronal cell death… (More)
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