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enalkiren

Known as: (Alpha-S)-Alpha-((Alpha-S)-Alpha-(3-Amino-3-Methylbutyramido)-p-Methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(Cyclohexylmethyl)-2,3-Dihydroxy-5-Methylhexyl)Imidazole-4-Propionamide, (N-(3-amino-3-methyl-1-oxobutyl)-4-methoxy-L-phenylalanyl)-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-L-histidinamide, L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))- 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

A 64662

Broader (2)

DipeptidesProtease Inhibitors

Papers overview

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1995
1995
Renal vascular responses to renin inhibition with zankiren in men
1995
1995
Intrarenal angiotensin II formation in humans. Evidence from renin inhibition.
Highly Cited
1994
Highly Cited
1994
Responses to converting enzyme and renin inhibition. Role of angiotensin II in humans.
We compared the renal vascular responses to angiotensin converting enzyme inhibition and renin inhibition to assess the influence… 
1992
1992
C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties.
We describe the development of a series of soluble, potent, and bioavailable nonpeptide renin inhibitors. These inhibitors… 
1991
1991
Renal and Endocrine Responses to a Renin Inhibitor, Enalkiren, in Normal Humans
Interpretation of renin-angiotensin blockade with angiotensin converting enzyme inhibitors is potentially confounded by their… 
1990
1990
Synthesis of polypeptides by microwave heating II. Function of polypeptides synthesized during repeated hydration-dehydration cycles
SummaryPolypeptides, synthesized from a mixture of amino acid amides by microwave heating during repeated hydration-dehydration… 
1990
1990
Prolonged Duration of Blood Pressure Response to Enalkiren, the Novel Dipeptide Renin Inhibitor, in Essential Hypertension
The effects of sustained renin inhibition by repeated administration of enalkiren (A- 64662), the novel dipeptide renin inhibitor… 
1990
1990
Effects of renin inhibition in systemic hypertension.
Review
1990
Review
1990
Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor.
Enalkiren (A-64662), a potent, dipeptide renin inhibitor, mimics the transition state of the human renin substrate… 
Highly Cited
1989
Highly Cited
1989
Hemodynamic and Humoral Effects of the New Renin Inhibitor Enalkiren in Normal Humans
The effect of the renin inhibitor enalkiren (Abbott- 64662) was evaluated in eight normal volunteer subjects on a standardized… 
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