edatrexate

Known as: 10-ethyl-10-deaza-aminopterin, 10-EDAM, 10-ethyl-10-deazaaminopterin 
A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
MOTIVATION Advancing the search, publication and integration of bioinformatics tools and resources demands consistent machine… (More)
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2010
2010
The EMBRACE (European Model for Bioinformatics Research and Community Education) web service collection is the culmination of a 5… (More)
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2010
2010
MOTIVATION The world-wide community of life scientists has access to a large number of public bioinformatics databases and tools… (More)
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2001
2001
The presence of sequence variants in the human reduced folate carrier (hRFC) was assessed in leukemia blasts from children with… (More)
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Highly Cited
2000
Highly Cited
2000
The blockade of epidermal growth factor receptor (EGFR) function with monoclonal antibodies has major antiproliferative effects… (More)
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Highly Cited
2000
Highly Cited
2000
Seven kinds of ripened cheeses (8-mo-aged and 24-mo-aged Gouda, Emmental, Blue, Camembert, Edam, and Havarti) were homogenized… (More)
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1995
1995
The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three… (More)
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1993
1993
Cytotoxicity studies combining edatrexate (EDX) and cisplatin (Cis-Pt) were carried out in HL-60 cells in vitro as a… (More)
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1992
1992
Efforts to use fresh human sarcoma cells for evaluating antifolate resistance with an in situ thymidylate synthesis assay using 5… (More)
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1990
1990
This study reports the isolation and characterization of a variant of the human CCRF-CEM leukemia cell line that overproduces the… (More)
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