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eIF-2 Kinase
Known as:
Controlled Repressor, Hemin
, Repressor, Hemin Controlled
, Protein Kinase, RNA Activated
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A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase…
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National Institutes of Health
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Related topics
Related topics
16 relations
EIF2AK2 gene
EIF2AK2 wt Allele
In Blood
PRKR gene
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Narrower (4)
EIF2AK2 protein, human
Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1
Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3, human
PERK kinase
Broader (1)
Protein-Serine-Threonine Kinases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
Liming Sun
,
Huayi Wang
,
+8 authors
Xiaodong Wang
Cell
2012
Corpus ID: 17832872
Highly Cited
2005
Highly Cited
2005
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
D. Sarbassov
,
D. Guertin
,
Siraj M. Ali
,
D. Sabatini
Science
2005
Corpus ID: 45837814
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires…
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Highly Cited
2004
Highly Cited
2004
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Umut Özcan
,
Qiong Cao
,
+7 authors
G. Hotamışlıgil
Science
2004
Corpus ID: 22517395
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell…
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Review
1998
Review
1998
Mechanisms and consequences of activation of protein kinase B/Akt.
J. Downward
Current Opinion in Cell Biology
1998
Corpus ID: 1683054
Highly Cited
1998
Highly Cited
1998
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
S. Arber
,
Freda A. Barbayannis
,
+4 authors
P. Caroni
Nature
1998
Corpus ID: 4394707
Cell division, cell motility and the formation and maintenance of specialized structures in differentiated cells depend directly…
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Highly Cited
1997
Highly Cited
1997
β‐catenin is a target for the ubiquitin–proteasome pathway
H. Aberle
,
A. Bauer
,
J. Stappert
,
A. Kispert
,
R. Kemler
1997
Corpus ID: 9561740
β‐catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling…
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Highly Cited
1995
Highly Cited
1995
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
B. Burgering
,
P. Coffer
Nature
1995
Corpus ID: 4348241
A serine/threonine kinase, named protein kinase B (PKB)1 for its sequence homology to both protein kinase A and C, has previously…
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Highly Cited
1995
Highly Cited
1995
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
B. Dérijard
,
J. Raingeaud
,
+4 authors
R. Davis
Science
1995
Corpus ID: 9153074
Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino…
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Highly Cited
1994
Highly Cited
1994
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
Eiichi Araki
,
Myra A. Lipes
,
+4 authors
C. R. Kahn
Nature
1994
Corpus ID: 4349934
THE principal substrate for the insulin and insulin-like growth factor-1 (IGF-1) receptors is the cytoplasmic protein insulin…
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Highly Cited
1993
Highly Cited
1993
cPLA2 is phosphorylated and activated by MAP kinase
Lih-Ling Lin
,
M. Wartmann
,
A. Y. Lin
,
J. Knopf
,
A. Seth
,
R. Davis
Cell
1993
Corpus ID: 1500909
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