eIF-2 Kinase

Known as: Controlled Repressor, Hemin, Repressor, Hemin Controlled, Protein Kinase, RNA Activated 
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Stimulation of human colon cancer cells with insulin-like growth factor 1 (IGF-1) induces expression of the VEGF gene, encoding… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2. Insulin induces dephosphorylation of eEF2 and… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Stabilization of mRNAs contributes to the strong and rapid induction of genes in the inflammatory response. The signaling… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
1999
Review
1999
The double stranded RNA (dsRNA)-activated protein kinase PKR is a ubiquitously expressed serine/threonine protein kinase that is… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The complex of rapamycin with its intracellular receptor, FKBP12, interacts with RAFT1/FRAP/mTOR, the in vivo rapamycin-sensitive… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
In response to various environmental stresses, eukaryotic cells down-regulate protein synthesis by phosphorylation of the alpha… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
A serine/threonine kinase, named protein kinase B (PKB)1 for its sequence homology to both protein kinase A and C, has previously… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino… (More)
Is this relevant?