Skip to search formSkip to main contentSkip to account menu

eIF-2 Kinase

Known as: Controlled Repressor, Hemin, Repressor, Hemin Controlled, Protein Kinase, RNA Activated 
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase… 
National Institutes of Health

Related topics

Related topics

16 relations
EIF2AK2 geneEIF2AK2 wt AlleleIn BloodPRKR gene

Narrower (4)

EIF2AK2 protein, humanEukaryotic Translation Initiation Factor 2-Alpha Kinase 1Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3, humanPERK kinase

Broader (1)

Protein-Serine-Threonine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Direct Phosphorylation of NF-κB1 p105 by the IκB Kinase Complex on Serine 927 Is Essential for Signal-induced p105 Proteolysis*
The p105 precursor protein of NF-κB1 acts as an NF-κB inhibitory protein, retaining associated Rel subunits in the cytoplasm of… 
Highly Cited
1998
Highly Cited
1998
A Role for the p38 Mitogen-activated Protein Kinase/Hsp 27 Pathway in Cholecystokinin-induced Changes in the Actin Cytoskeleton in Rat Pancreatic Acini*
Cholecystokinin (CCK) and other pancreatic secretagogues have recently been shown to activate signaling kinase cascades in… 
Highly Cited
1997
Highly Cited
1997
Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway
Activation of early response genes by interferons (IFNs) and other cytokines requires tyrosine phosphorylation of a family of… 
Highly Cited
1995
Highly Cited
1995
Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts.
MAP kinase (mitogen activated protein kinase) represents a ubiquitously expressed family of kinases whose long term activation… 
Highly Cited
1995
Highly Cited
1995
NDF/heregulin activates MAP kinase and p70/p85 S6 kinase during proliferation or differentiation of mammary epithelial cells.
Neu differentiation factors (NDF) are a novel family of polypeptide factors which activate sub-class I tyrosine kinase receptors… 
Highly Cited
1993
Highly Cited
1993
Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine.
Highly Cited
1989
Highly Cited
1989
Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals.
A protein of 87 kilodaltons (87 kDa) was previously identified as a major specific substrate for protein kinase C in neuronal and… 
Highly Cited
1986
Highly Cited
1986
Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells.
The treatment of PC12 cells with either nerve growth factor or phorbol 12-myristate 13-acetate caused a decrease in the… 
Highly Cited
1985
Highly Cited
1985
The chromone inhibitor stigmatellin ‐ binding to the ubiquinol oxidation center at the C‐side of the mitochondrial membrane
Highly Cited
1985
Highly Cited
1985
A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity
We constructed a mutant, called RSV-SF2, at the ATP-binding site of pp60v-src. In this mutant, lysine-295 is replaced with… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)