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duocarmycin A

Known as: Cyclopropa(c)pyrrolo(3,2-e)indole-6-carboxylic acid, 1,2,4,5,6,7,8,8a-octahydro-6-methyl-4,7-dioxo-2-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Alkylating AgentsIndolesPyrrolidinones
duocarmycine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Sequence-specific alkylation of DNA by duocarmycin A and its novel derivatives bearing PY/IM polyamides.
A new class of sequence-specific DNA alkylating agents were developed based on the reactivity of duocarmycin A and the DNA… 
1996
1996
Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A.
Duocarmycin A (Duo) normally alkylates adenine N3 at the 3' end of A + T-rich sequences in DNA. The efficient adenine alkylation… 
1995
1995
Efficient guanine alkylation through cooperative heterodimeric formation of duocarmycin A and distamycin A.
Antitumor antibiotic Duocarmycin A alkylates adenines at the 3 end of sequences of three or more consecutive A or T base pairs… 
1993
1993
Concerted DNA recognition and novel site-specific alkylation by duocarmycin A with distamycin A.
Duocarmycin A, a novel antitumor antibiotic, has a reactive cyclopropane ring, which has been reported to alkylate adenine at the… 
1993
1993
Sequence-selective guanine reactivity by duocarmycin A.
High selectivity for covalent reaction at adenine N-3 within duplex DNA is a distinguishing feature of the CC-1065 and… 
1991
1991
Site specific covalent alkylation of DNA by antitumor antibiotics, duocarmycin A and kapurimycin A3.
DNA alkylation by two different antitumor antibiotics, duocarmycin A and kapurimycin A3 was investigated by using of synthetic… 
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