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doxorubicin-HPMA conjugate

Known as: HPMA-doxorubicin, Doxorubicin-HPMA Copolymer Conjugate, Doxorubicin-HPMA 
A copolymer conjugate of the antineoplastic anthracycline doxorubicin and the water-soluble polymer N-(2-hydroxypropyl) methacrylamide (HPMA… 
National Institutes of Health

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PK1 doxorubicin-HPMA conjugate

Papers overview

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2019
2019
The influence of gradient and statistical arrangements of guanidinium or primary amine groups in poly(methacrylate) copolymers on their DNA binding affinity.
Herein, we report the first gradient guanidinium containing cationic copolymers and investigate their binding ability to plasmid… 
2017
2017
pH-Responsive, Amphiphilic Core-Shell Supramolecular Polymer Brushes from Cyclic Peptide-Polymer Conjugates.
The synthesis and self-assembly of pH-responsive, amphiphilic cyclic peptide-polymer conjugates are described. The design relies… 
2012
2012
Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery.
Review
2011
Review
2011
Targeted TFO delivery to hepatic stellate cells.
Highly Cited
2004
Highly Cited
2004
Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasis.
2003
2003
Starlike vs. Classic Macromolecular Prodrugs: Two Different Antibody-Targeted HPMA Copolymers of Doxorubicin Studied in Vitro and in Vivo as Potential Anticancer Drugs
AbstractPurpose. Two different monoclonal antibody-targeted HPMA copolymer-doxorubicin conjugates, classic and starlike, were… 
2002
2002
HPMA-hydrogels result in prolonged delivery of anticancer drugs and are a promising tool for the treatment of sensitive and multidrug resistant leukaemia.
2001
2001
N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation.
Ellipticine derivatives have potential as anticancer drugs. Their clinical use has been limited, however, by poor solubility and… 
2000
2000
HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 3. The effect of free and polymer-bound adriamycin on the expression of some genes in the OVCAR-3 human ovarian carcinoma cell line.
1996
1996
Gamma scintigraphy of a 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate containing galactosamine following intravenous administration to nude mice bearing hepatic…
Polymer drug conjugates composed of N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer covalently bound doxorubicin, and… 
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