doxorubicin-DNA

Known as: Doxorubicin-DNA Complex, DOX-DNA, Adriamycin-DNA Complex 
A complex comprised of Doxorubicin linked to DNA to enhance the topoisomerase II-mediated interaction with the DNA base pairs and reduce… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2017
024619742017

Papers overview

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2014
2014
The intercalation of antitumor drug doxorubicin (DOX) and its analogue N-(trifluoroacetyl) doxorubicin (FDOX) with DNA duplex was… (More)
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2012
2012
The cytotoxicity of doxorubicin, a clinically used anti-neoplastic drug, can be enhanced by formaldehyde (either endogenous or… (More)
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2010
2010
Doxorubicin is an anthracycline anticancer agent that functions primarily by inhibiting topoisomerase II, but also forms covalent… (More)
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2007
2007
The importance of understanding the mechanism of action of anticancer agents is sometimes overlooked in the pursuit of new and… (More)
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Highly Cited
2006
Highly Cited
2006
Doxorubicin (Adriamycin) is one of the most commonly used chemotherapeutic drugs and exhibits a wide spectrum of activity against… (More)
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1998
1998
Adriamycin is a popular antineoplastic agent whose ability to form covalent adducts with DNA has been correlated to cellular… (More)
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1998
1998
The antitumor antibiotic doxorubicin was conjugated with polymeric dextrans of various molecular weights and the cytotoxicity of… (More)
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1990
1990
Initiated transcription complexes were exposed to adriamycin for up to 48 h. Subsequent elongation of the transcription complex… (More)
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1984
1984
Among the effects exerted by adriamycin (ADR), interaction with DNA is closely related to cytotoxicity. The interaction results… (More)
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1979
1979
We have compared the toxicologic, pharmacologic, and therapeutic properties of the DNA complexes of daunorubicin and doxorubicin… (More)
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