double-strand break repair via homologous recombination

Known as: Rad51-dependent recombinational repair, HRR, Recombinational Repair of DNA 
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1940-2017
050019402016

Papers overview

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Review
2016
Review
2016
BACKGROUND The genome is under constant assault from a multitude of sources that can lead to the formation of DNA double-stand… (More)
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Highly Cited
2014
Highly Cited
2014
Although both homologous recombination (HR) and nonhomologous end joining can repair DNA double-strand breaks (DSBs), the… (More)
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Highly Cited
2013
Highly Cited
2013
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II… (More)
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Highly Cited
2011
Highly Cited
2011
Breast cancer suppressor BRCA2 is critical for maintenance of genomic integrity and resistance to agents that damage DNA or… (More)
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Highly Cited
2010
Highly Cited
2010
Defective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals… (More)
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Highly Cited
2009
Highly Cited
2009
Homologous recombination (HR) and non-homologous end joining (NHEJ) represent distinct pathways for repairing DNA double-strand… (More)
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Highly Cited
2004
Highly Cited
2004
The two major pathways for repairing double-strand breaks (DSBs), homologous recombination and nonhomologous end joining (NHEJ… (More)
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Highly Cited
1998
Highly Cited
1998
A straightforward way to engineer DNA in E. coli using homologous recombination is described. The homologous recombination… (More)
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Highly Cited
1997
Highly Cited
1997
When gene conversion is initiated by a double-strand break (DSB), any nonhomologous DNA that may be present at the ends must be… (More)
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Highly Cited
1997
Highly Cited
1997
We report here that DNA double-strand breaks (DSBs) form in Escherichia coli upon arrest of replication forks due to a defect in… (More)
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