double-strand break repair via homologous recombination

Known as: Rad51-dependent recombinational repair, HRR, Recombinational Repair of DNA 
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1939-2018
020040019392017

Papers overview

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Review
2016
Review
2016
Despite nearly complete understanding of the genetics of the β-hemoglobinopathies for several decades, definitive treatment… (More)
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Highly Cited
2013
Highly Cited
2013
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II… (More)
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Highly Cited
2011
Highly Cited
2011
Breast cancer suppressor BRCA2 is critical for maintenance of genomic integrity and resistance to agents that damage DNA or… (More)
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Highly Cited
2009
Highly Cited
2009
Homologous recombination (HR) and non-homologous end joining (NHEJ) represent distinct pathways for repairing DNA double-strand… (More)
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Highly Cited
2009
Highly Cited
2009
To maintain genome stability, cells respond to DNA damage by activating signalling pathways that govern cell-cycle checkpoints… (More)
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Highly Cited
2009
Highly Cited
2009
Mutations in breast cancer susceptibility gene 1 and 2 (BRCA1 and BRCA2) predispose individuals to breast and ovarian cancer… (More)
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Highly Cited
2009
Highly Cited
2009
The epidermal growth factor receptor (EGFR) is frequently dysregulated in malignant glioma that leads to increased resistance to… (More)
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Highly Cited
2008
Highly Cited
2008
Homologous recombination (HR) is an important conserved process for DNA repair and ensures maintenance of genome integrity… (More)
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Highly Cited
2005
Highly Cited
2005
Histone variant H2AX phosphorylation in response to DNA damage is the major signal for recruitment of DNA-damage-response… (More)
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Highly Cited
2004
Highly Cited
2004
Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer… (More)
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