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dolastatin 10

Known as: Dolastatin-10, L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]], isodolastatin 10 
A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin… Expand
National Institutes of Health

Related topics

Related topics

9 relations

Broader (3)

Antineoplastic AgentsDepsipeptidesTubulin Modulators
Microtubule ProcessNegative Regulation of MitosisPositive Regulation of ApoptosisTubulin

Narrower (2)

NSC 376128deo-dolastatin 10

Papers overview

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Highly Cited
2009
Highly Cited
2009
Marine Natural Products and Their Potential Applications as Anti-Infective Agents
2 Abstract: Extracts of marine algae, sponge and humic acid sediments were tested against different bacterial pathogens by well… Expand
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Highly Cited
2008
Highly Cited
2008
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
A novel cytotoxic cyclodepsipeptide, termed largazole (1), has been isolated from the marine cyanobacterium Symploca sp… Expand
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Highly Cited
2003
Highly Cited
2003
The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog
Symplostatin 1, an analog of dolastatin 10, was recently isolated from cyanobacteria of the genus Symploca. Symplostatin 1 is a… Expand
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Highly Cited
2001
Highly Cited
2001
Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report… Expand
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Highly Cited
2000
Highly Cited
2000
Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma.
Dolastatin-10 is a natural, cytotoxic peptide with microtubule-inhibitory and apoptotic effects. It has demonstrated in vitro and… Expand
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Highly Cited
1998
Highly Cited
1998
Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides.
A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca… Expand
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Highly Cited
1992
Highly Cited
1992
Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.
Dolastatin 15, a seven-subunit depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally… Expand
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Highly Cited
1991
Highly Cited
1991
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60… Expand
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Highly Cited
1990
Highly Cited
1990
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
Dolastatin 10, a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly, tubulin-dependent GTP… Expand
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Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was isolated from the marine shell-less… Expand
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