Skip to search formSkip to main contentSkip to account menu

dolastatin 10

Known as: Dolastatin-10, L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]], isodolastatin 10 
A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (3)

Antineoplastic AgentsDepsipeptidesTubulin Modulators
Microtubule ProcessNegative Regulation of MitosisPositive Regulation of ApoptosisTubulin

Narrower (2)

NSC 376128deo-dolastatin 10

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and…
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the… 
Highly Cited
2008
Highly Cited
2008
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
A novel cytotoxic cyclodepsipeptide, termed largazole (1), has been isolated from the marine cyanobacterium Symploca sp… 
Highly Cited
2003
Highly Cited
2003
Development of potent monoclonal antibody auristatin conjugates for cancer therapy
We describe the in vitro and in vivo properties of monoclonal antibody (mAb)-drug conjugates consisting of the potent synthetic… 
Review
2003
Review
2003
Marine natural products and their potential applications as anti-infective agents
Highly Cited
2001
Highly Cited
2001
Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report… 
Review
2001
Review
2001
Marine organisms as a source of new anticancer agents.
Highly Cited
2000
Highly Cited
2000
Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma.
Dolastatin-10 is a natural, cytotoxic peptide with microtubule-inhibitory and apoptotic effects. It has demonstrated in vitro and… 
Highly Cited
1998
Highly Cited
1998
Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides.
A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca… 
Highly Cited
1991
Highly Cited
1991
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
Highly Cited
1990
Highly Cited
1990
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License