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dolastatin 10

Known as: Dolastatin-10, L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]], isodolastatin 10 
A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (3)

Antineoplastic AgentsDepsipeptidesTubulin Modulators
Microtubule ProcessNegative Regulation of MitosisPositive Regulation of ApoptosisTubulin

Narrower (2)

NSC 376128deo-dolastatin 10

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Research advances on marine antitumor peptides dolastatin 10
] Dolastatin 10,a cytostatic depsipeptide containing four unique amino acid subunits,was isolated from the marine shell-less… 
2005
2005
Phase I and Pharmacokinetic Study of the Dolastatin 10 Analogue TZT-1027 , Given on Days 1 and 8 of a 3-Week Cycle in Patientswith Advanced SolidTumors
Purpose: TZT-1027 {N-(N,N-dimethyl-L-valyl)-N-[(1S ,2R)-2-methoxy-4-[(2S)-2[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl… 
2002
2002
Dolastatin 10 derivatives
The present invention relates to new compounds of formula I, having an anti-tumor activity, wherein R1, R2, R3, R4, R5 and n are… 
2002
2002
Dolastatin 10 derivatives
Novel anti-tumor compounds of formula, are disclosed. Also disclosed are pharmaceutical compositions comprising compounds of… 
2002
2002
Dolastatin 10 derivatives
The present invention is concerned with anti-tumor activity relates to new compounds, and their pharmaceutically acceptable salts… 
2000
2000
Phase II Study of Dolastatin-10 in Patients with Hormone-refractory Metastatic Prostate Adenocarcinoma 1
Dolastatin-10 is a natural, cytotoxic peptide with microtubule-inhibitory and apoptotic effects. It has demonstratedin vitro and… 
1999
1999
Clinical trials referral resource. Clinical trials of dolastatin-10.
1999
1999
CLINICAL TRIALS OF DOLASTATIN-10
1993
1993
Dolastatin 10 derivative
PURPOSE: To obtain a new dolastatin 10 derivative useful to suppress the multiplication of leukemia, non-small cell lung cancer… 
1991
1991
Antineoplastic dolastatins: potent inhibitors of hematopoietic progenitor cells.
Dolastatins 10 and 15, isolated from the shell-less marine mollusk Dolabella auricularia, are potent antineoplastic agents with… 
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