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dolastatin 10

Known as: Dolastatin-10, L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]], isodolastatin 10 
A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin… Expand
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
2 Abstract: Extracts of marine algae, sponge and humic acid sediments were tested against different bacterial pathogens by well… Expand
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Highly Cited
2008
Highly Cited
2008
A novel cytotoxic cyclodepsipeptide, termed largazole (1), has been isolated from the marine cyanobacterium Symploca sp… Expand
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Highly Cited
2003
Highly Cited
2003
Symplostatin 1, an analog of dolastatin 10, was recently isolated from cyanobacteria of the genus Symploca. Symplostatin 1 is a… Expand
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Highly Cited
2001
Highly Cited
2001
The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report… Expand
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Highly Cited
2000
Highly Cited
2000
Dolastatin-10 is a natural, cytotoxic peptide with microtubule-inhibitory and apoptotic effects. It has demonstrated in vitro and… Expand
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Highly Cited
1998
Highly Cited
1998
A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca… Expand
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Highly Cited
1992
Highly Cited
1992
Dolastatin 15, a seven-subunit depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally… Expand
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Highly Cited
1991
Highly Cited
1991
Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60… Expand
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Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly, tubulin-dependent GTP… Expand
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Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was isolated from the marine shell-less… Expand
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