dolastatin 10

Known as: Dolastatin-10, L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]], isodolastatin 10 
A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin… (More)
National Institutes of Health

Related topics

Related topics

9 relations

Broader (3)

Antineoplastic AgentsDepsipeptidesTubulin Modulators
Microtubule ProcessNegative Regulation of MitosisPositive Regulation of ApoptosisTubulin

Narrower (2)

NSC 376128deo-dolastatin 10

Papers overview

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2014
2014
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
Auristatins, synthetic analogues of the antineoplastic natural product Dolastatin 10, are ultrapotent cytotoxic microtubule… (More)
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Highly Cited
2006
Highly Cited
2006
Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells.
The antidyslipidemic drug nicotinic acid (niacin) has been used for decades. One of the major problems of the therapeutical use… (More)
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Highly Cited
2003
Highly Cited
2003
Development of potent monoclonal antibody auristatin conjugates for cancer therapy
We describe the in vitro and in vivo properties of monoclonal antibody (mAb)-drug conjugates consisting of the potent synthetic… (More)
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Review
2001
Review
2001
Marine organisms as a source of new anticancer agents.
Various active anticancer agents are derived from plants and terrestrial microorganisms. The isolation of C-nucleosides from the… (More)
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2000
2000
Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.
Dolastatin 10 is a highly cytotoxic antimitotic peptide in phase II clinical trials. Its cytotoxicity has been as much as 50-fold… (More)
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2000
2000
Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma.
Dolastatin-10 is a natural, cytotoxic peptide with microtubule-inhibitory and apoptotic effects. It has demonstrated in vitro and… (More)
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1999
1999
Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance
Purpose: Dolastatin 10 (DOL 10), an oligopeptide isolated from the sea hare Dolabella auricularia, has been shown to be a highly… (More)
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1998
1998
Antineoplastic agents 365. Dolastatin 10 SAR probes.
The remarkable anticancer drug dolastatin 10 (1a) from the Indian Ocean sea hare Dolabella auricularia is currently undergoing… (More)
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1995
1995
Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.
We have prepared [3H]dolastatin 10 and examined its interactions with tubulin. Binding kinetics appeared to be biphasic, with a… (More)
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Highly Cited
1990
Highly Cited
1990
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
Dolastatin 10, a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly, tubulin-dependent GTP… (More)
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