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dofetilide

Known as: Dofetilida, 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane, beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide 
A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component… 
National Institutes of Health

Related topics

Related topics

20 relations
AmiodaroneAtrial FibrillationAtrial FlutterCimetidine

Broader (4)

Anti-Arrhythmia AgentsPhenethylaminesPotassium Channel BlockersSulfonamides

Narrower (1)

UK 68798

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents.
Highly Cited
2010
Highly Cited
2010
Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study.
Highly Cited
2007
Highly Cited
2007
Combined pharmacological block of IKr and IKs increases short‐term QT interval variability and provokes torsades de pointes
Assessing the proarrhythmic potential of compounds during drug development is essential. However, reliable prediction of drug… 
Highly Cited
2006
Highly Cited
2006
RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents.
2005
2005
Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs.
Highly Cited
2003
Highly Cited
2003
Detection of Proarrhythmia in the Female Rabbit Heart:
Introduction: Reliable detection of drug‐induced proarrhythmia, especially the potential for polymorphic ventricular tachycardia… 
Highly Cited
2002
Highly Cited
2002
Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations.
Highly Cited
1997
Highly Cited
1997
Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes.
A variety of class III antiarrhythmic agents have been shown to block the delayed rectifier current, but their effects on other K… 
Highly Cited
1997
Highly Cited
1997
Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells.
Two characteristic features of the rapid component of the cardiac delayed rectifier current (IKr) are prominent inward… 
Highly Cited
1996
Highly Cited
1996
Influence of dofetilide on QT-interval duration and dispersion at various heart rates during exercise in humans.
BACKGROUND The objective of this study was to assess the influence of heart rate on QT-interval duration and dispersion during… 
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