dofetilide

Known as: Dofetilida, 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane, beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide 
A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component… (More)
National Institutes of Health

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Highly Cited
2000
Highly Cited
2000
BACKGROUND This double-blind, multicenter, placebo-controlled study determined the efficacy and safety of dofetilide in… (More)
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Highly Cited
2000
Highly Cited
2000
This study reports that the affinity of HERG1 A for dofetilide is decreased from 0.125 +/- 0.003 microM for wild-type (WT… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Arrhythmias cause much morbidity and mortality after myocardial infarction, but in previous trials, antiarrhythmic… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Atrial fibrillation occurs frequently in patients with congestive heart failure and commonly results in clinical… (More)
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Highly Cited
1998
Highly Cited
1998
We have derived a cardiac muscle cell line, designated HL-1, from the AT-1 mouse atrial cardiomyocyte tumor lineage. HL-1 cells… (More)
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Highly Cited
1998
Highly Cited
1998
The human ether-a-go-go-related gene (HERG) encodes a K+ channel with biophysical properties nearly identical to the rapid… (More)
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Highly Cited
1996
Highly Cited
1996
In the long QT syndrome, excessive prolongation of the cardiac action potential leads to polymorphic ventricular tachycardia… (More)
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Highly Cited
1993
Highly Cited
1993
Class III antiarrhythmic agents act by selective prolongation of cardiac action potential duration (APD). Methanesulfonanilide… (More)
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Highly Cited
1992
Highly Cited
1992
The delayed K+ current (ik) and its change by dofetilide was studied in single myocytes from the guinea pig and rabbit heart… (More)
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