FAQ

ditercalinium

Known as: 2,2'-((4,4'-Bipiperidine)-1,1'-Diyldiethylene)Bis(10-Methoxy-7H-Pyrido(4,3-c)Carbazolium) 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2012
0246819842012

Related topics

Related topics

6 relations

Broader (3)

Antineoplastic AgentsCarbazolesIntercalating Agents

Narrower (2)

NSC 335153NSC 366241
ditercalinium chloride

Related mentions per year

Related mentions per year

1947-2018
19401960198020002020
ditercalinium
Antineoplastic Agents
Intercalating Agents
Carbazoles
NSC 335153
NSC 366241

Papers overview

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2003
2003
Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication
Ditercalinium chloride was originally synthesized for use as an anticancer drug and was then found to deplete mitochondrial DNA… (More)
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2002
2002
Tight binding of the antitumor drug ditercalinium to quadruplex DNA.
The structural selectivity of the DNA-binding antitumor drug ditercalinium was investigated by competition dialysis with a series… (More)
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2002
2002
DNA sequence recognition by the antitumor drug ditercalinium.
The antitumor drug ditercalinium is a rare example of a noncovalent DNA-binding ligand that forms bisintercalation complexes via… (More)
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2002
2002
Structural perturbations in DNA caused by bis-intercalation of ditercalinium visualised by atomic force microscopy
Atomic force microscopy (AFM) has been used to examine perturbations in the tertiary structure of DNA induced by the binding of… (More)
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1992
1992
DNA-ditercalinium interactions: implications for recognition of damaged DNA.
Ditercalinium is unique among known DNA-binding chemotherapeutic agents. Ditercalinium treatment of Escherichia coli causes cell… (More)
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1991
1991
Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex.
Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In… (More)
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1990
1990
DNase I susceptibility of bent DNA and its alteration by ditercalinium and distamycin.
The bending of kinetoplast DNA from Crithidia fasciculata is thought to be related to the periodic distribution of AA or TT… (More)
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1990
1990
Selective alteration of mitochondrial function by Ditercalinium (NSC 335153), a DNA bisintercalating agent.
The bifunctional intercalator Ditercalinium (NSC 335153) demonstrates an anti-tumoral cytotoxicity markedly different from other… (More)
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1988
1988
Cytoplasmic accumulation of ditercalinium in rat hepatocytes and induction of mitochondrial damage.
Ditercalinium (NSC 335153), a 7H-pyridocarbazole dimer, is a bis-intercalating agent whose mechanism of action differs from that… (More)
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1986
1986
Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II.
Ditercalinium, a 7H-pyridocarbazole dimer (bisintercalator) belongs to a new class of antineoplastic intercalating agents. To… (More)
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