Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ditercalinium

Known as: 2,2'-((4,4'-Bipiperidine)-1,1'-Diyldiethylene)Bis(10-Methoxy-7H-Pyrido(4,3-c)Carbazolium) 
 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Antineoplastic AgentsCarbazolesIntercalating Agents

Narrower (3)

NSC 335153NSC 366241ditercalinium chloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Tight Binding of the Antitumor Drug Ditercalinium to Quadruplex DNA
The structural selectivity of the DNA‐binding antitumor drug ditercalinium was investigated by competition dialysis with a series… Expand
Highly Cited
2002
Highly Cited
2002
Structural perturbations in DNA caused by bis-intercalation of ditercalinium visualised by atomic force microscopy
Atomic force microscopy (AFM) has been used to examine perturbations in the tertiary structure of DNA induced by the binding of… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
2002
2002
Synthesis, cytotoxic activities and proposed mode of binding of a series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines.
A series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines have been prepared and their antiproliferative… Expand
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
1997
1997
Isolation and characterization of mitochondrial DNA-less lines from various mammalian cell lines by application of an anticancer drug, ditercalinium.
Since ethidium bromide was not effective in mouse cell lines for isolating mitochondrial DNA (mtDNA)-less cells (rho zero cells… Expand
Highly Cited
1993
Highly Cited
1993
Inhibitors of human immunodeficiency virus integrase.
In an effort to further extend the number of targets for development of antiretroviral agents, we have used an in vitro integrase… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Highly Cited
1991
Highly Cited
1991
Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex.
Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
1988
1988
Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent.
Ditercalinium (NSC 335153), a bifunctional intercalating molecule with antitumor activity, is found to express its toxicity… Expand
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
1988
1988
Induction of an abortive and futile DNA repair process in E. coli by the antitumor DNA bifunctional intercalator, ditercalinium: role in polA in death induction.
Ditercalinium, an antitumor bifunctional intercalator which forms a high affinity reversible complex with DNA, was found to be… Expand
  • table 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
1987
1987
Bisintercalation of ditercalinium into a d[CpGpCpG]2 minihelix: Structure and dynamics aspects—a 400‐MHz 1H‐nmr study
The structure of the complex formed in aqueous solution at pH 5.5 between ditercalinium, a potent antitumoral 7H‐pyrido[4,3‐c… Expand
1986
1986
Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II.
Ditercalinium, a 7H-pyridocarbazole dimer (bisintercalator) belongs to a new class of antineoplastic intercalating agents. To… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE