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ditekiren

Known as: Boc-Pro-Phe-N-MeHis-Leu(psi)(CHOHCH2)Val-Ile-2-aminomethylpyridine, L-Histidinamide, 1-((1,1-Dimethylethoxy)Carbonyl)-L-Prolyl-L-Phenylalanyl-N-(2-Hydroxy-5-Methyl-1-(2-Methylpropyl)-4-(((2-Methyl-1-(((2-Pyridinylmethyl)Amino)Carbonyl)Butyl)Amino)Carbonyl)Hexyl)-N(Sup Alpha)-Methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))- 
National Institutes of Health

Papers overview

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2004
2004
Ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. Preclinical drug safety studies with this drug… 
2004
2004
Ditekiren (U-71038; Boc-Pro-Phe-N-MeHis-Leu-Ψ[CHOHCH2]-Val-Ile-aminomethyl)pyridine) is a potent renin inhibitor peptide and was… 
1997
1997
Many small oligopeptides are rapidly excreted unchanged into bile, which requires vectorial transport across the hepatocyte. To… 
1993
1993
Oligopeptides developed as potential therapeutic agents are often limited in their duration of action because of rapid… 
1993
1993
To evaluate the bile acid transporter as a means of enhancing the ability of renin-inhibitory peptides (RIPs) to penetrate the… 
1991
1991
A fluorescent human renin inhibitor, dansyl-Phe-His-LVA-Ile-Amp (3, U-80,825), was synthesized and utilized in a fluorescence… 
1990
1990