ditekiren

Known as: Boc-Pro-Phe-N-MeHis-Leu(psi)(CHOHCH2)Val-Ile-2-aminomethylpyridine, L-Histidinamide, 1-((1,1-Dimethylethoxy)Carbonyl)-L-Prolyl-L-Phenylalanyl-N-(2-Hydroxy-5-Methyl-1-(2-Methylpropyl)-4-(((2-Methyl-1-(((2-Pyridinylmethyl)Amino)Carbonyl)Butyl)Amino)Carbonyl)Hexyl)-N(Sup Alpha)-Methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))- 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2000
012319852000

Papers overview

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2000
2000
Sister of P-glycoprotein (SPGP), a novel murine cDNA and member of the ATP-binding cassette superfamily highly homologous to P… (More)
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1997
1997
Many small oligopeptides are rapidly excreted unchanged into bile, which requires vectorial transport across the hepatocyte. To… (More)
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1997
1997
The hepatic elimination of many oligopeptides is both rapid and extensive, and often limits their potential as therapeutic agents… (More)
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1994
1994
Among the limitations to the practical therapeutic oligopeptide are low oral availability, indifferent aqueous solubility, and an… (More)
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1993
1993
Oligopeptides developed as potential therapeutic agents are often limited in their duration of action because of rapid… (More)
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1993
1993
We showed previously that a commercially available synthetic tetradecapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val… (More)
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1991
1991
Additive combination studies of an angiotensin converting enzyme (ACE) inhibitor, captopril, and a renin inhibitor, ditekiren (U… (More)
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1991
1991
Ditekiren (U-71038; Boc-Pro-Phe-N-MeHis-Leu-Ψ[CHOHCH2]-Val-Ile-aminomethyl)pyridine) is a potent renin inhibitor peptide and was… (More)
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1991
1991
Ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. Preclinical drug safety studies with this drug… (More)
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1985
1985
Protein-bound N(τ)-methylhistidine (N-MeHis) has been suggested as an index for the estimation of muscle (meat) protein in meat… (More)
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