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ditekiren

Known as: Boc-Pro-Phe-N-MeHis-Leu(psi)(CHOHCH2)Val-Ile-2-aminomethylpyridine, L-Histidinamide, 1-((1,1-Dimethylethoxy)Carbonyl)-L-Prolyl-L-Phenylalanyl-N-(2-Hydroxy-5-Methyl-1-(2-Methylpropyl)-4-(((2-Methyl-1-(((2-Pyridinylmethyl)Amino)Carbonyl)Butyl)Amino)Carbonyl)Hexyl)-N(Sup Alpha)-Methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))- 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

OligopeptidesProtease Inhibitors

Narrower (1)

U 71038

Papers overview

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2004
2004
Precipitation of the Renin Inhibitor Ditekiren Upon iv Infusion; in Vitro Studies and Their Relationship to in Vivo Precipitation in the Cynomolgus Monkey
Ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. Preclinical drug safety studies with this drug… 
1993
1993
Development of Activity Assays for High-Volume Evaluation of Human Immunodeficiency Virus (HIV) Protease Inhibitors in Rat Serum: Results with Ditekiren
We showed previously that a commercially available synthetic tetradecapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val… 
1991
1991
Determination of dissociation constants of high affinity (pM) human renin inhibitors: application to analogues of ditekiren (U-71,038).
A fluorescent human renin inhibitor, dansyl-Phe-His-LVA-Ile-Amp (3, U-80,825), was synthesized and utilized in a fluorescence… 
1991
1991
Additive combination studies of captopril and ditekiren, a renin inhibitor, in nonhuman primates.
Additive combination studies of an angiotensin converting enzyme (ACE) inhibitor, captopril, and a renin inhibitor, ditekiren (U… 
1991
1991
In Vitro Evaluation of the Plasma and Blood Compatibility of a Parenteral Formulation for Ditekiren, a Novel Renin Inhibitor Pseudopeptide
Ditekiren (U-71038; Boc-Pro-Phe-N-MeHis-Leu-Ψ[CHOHCH2]-Val-Ile-aminomethyl)pyridine) is a potent renin inhibitor peptide and was… 
1991
1991
Validation of an immunoradiometric assay to measure plasma levels of active renin
An immunoradiometric assay (IRMA) for active renin in human plasma was analytically and clinically validated. Analytical… 
1990
1990
Rat model for evaluating inhibitors of human renin.
1990
1990
A primate bioassay for the determination of renin inhibitory peptides in serum.
1987
1987
Investigation of the levels of N(τ)-methylhistidine in a range of pork and chicken meats.
1985
1985
Investigation of the levels of N(τ)-Methylhistidine in a range of beef cuts and offals.
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