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ditekiren

Known as: Boc-Pro-Phe-N-MeHis-Leu(psi)(CHOHCH2)Val-Ile-2-aminomethylpyridine, L-Histidinamide, 1-((1,1-Dimethylethoxy)Carbonyl)-L-Prolyl-L-Phenylalanyl-N-(2-Hydroxy-5-Methyl-1-(2-Methylpropyl)-4-(((2-Methyl-1-(((2-Pyridinylmethyl)Amino)Carbonyl)Butyl)Amino)Carbonyl)Hexyl)-N(Sup Alpha)-Methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))- 
 
National Institutes of Health

Papers overview

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2004
2004
Ditekiren (U-71038; Boc-Pro-Phe-N-MeHis-Leu-Ψ[CHOHCH2]-Val-Ile-aminomethyl)pyridine) is a potent renin inhibitor peptide and was… Expand
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2004
2004
We showed previously that a commercially available synthetic tetradecapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val… Expand
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2000
2000
Sister of P-glycoprotein (SPGP), a novel murine cDNA and member of the ATP-binding cassette superfamily highly homologous to P… Expand
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1997
1997
Many small oligopeptides are rapidly excreted unchanged into bile, which requires vectorial transport across the hepatocyte. To… Expand
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1993
1993
Oligopeptides developed as potential therapeutic agents are often limited in their duration of action because of rapid… Expand
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1993
1993
To evaluate the bile acid transporter as a means of enhancing the ability of renin-inhibitory peptides (RIPs) to penetrate the… Expand
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1991
1991
Ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. Preclinical drug safety studies with this drug… Expand
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1991
1991
Additive combination studies of an angiotensin converting enzyme (ACE) inhibitor, captopril, and a renin inhibitor, ditekiren (U… Expand
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1991
1991
A fluorescent human renin inhibitor, dansyl-Phe-His-LVA-Ile-Amp (3, U-80,825), was synthesized and utilized in a fluorescence… Expand
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1985
1985
Protein-bound N(τ)-methylhistidine (N-MeHis) has been suggested as an index for the estimation of muscle (meat) protein in meat… Expand
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