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ditekiren

Known as: Boc-Pro-Phe-N-MeHis-Leu(psi)(CHOHCH2)Val-Ile-2-aminomethylpyridine, L-Histidinamide, 1-((1,1-Dimethylethoxy)Carbonyl)-L-Prolyl-L-Phenylalanyl-N-(2-Hydroxy-5-Methyl-1-(2-Methylpropyl)-4-(((2-Methyl-1-(((2-Pyridinylmethyl)Amino)Carbonyl)Butyl)Amino)Carbonyl)Hexyl)-N(Sup Alpha)-Methyl-, (1S-(1R*,2R*,4R*(1R*,2R*)))- 
 
National Institutes of Health

Papers overview

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2004
2004
Ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. Preclinical drug safety studies with this drug… Expand
2004
2004
Ditekiren (U-71038; Boc-Pro-Phe-N-MeHis-Leu-Ψ[CHOHCH2]-Val-Ile-aminomethyl)pyridine) is a potent renin inhibitor peptide and was… Expand
Highly Cited
2000
Highly Cited
2000
Sister of P-glycoprotein (SPGP), a novel murine cDNA and member of the ATP-binding cassette superfamily highly homologous to P… Expand
1997
1997
Many small oligopeptides are rapidly excreted unchanged into bile, which requires vectorial transport across the hepatocyte. To… Expand
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1994
1994
Among the limitations to the practical therapeutic oligopeptide are low oral availability, indifferent aqueous solubility, and an… Expand
1993
1993
Oligopeptides developed as potential therapeutic agents are often limited in their duration of action because of rapid… Expand
1993
1993
To evaluate the bile acid transporter as a means of enhancing the ability of renin-inhibitory peptides (RIPs) to penetrate the… Expand
1991
1991
A fluorescent human renin inhibitor, dansyl-Phe-His-LVA-Ile-Amp (3, U-80,825), was synthesized and utilized in a fluorescence… Expand
1987
1987
Protein bound N(τ)-methylhistidine (N-MeHis) has been suggested as an index for the estimation of muscle (meat) protein in meat… Expand
1985
1985
Protein-bound N(τ)-methylhistidine (N-MeHis) has been suggested as an index for the estimation of muscle (meat) protein in meat… Expand