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disobutamide

Known as: alpha-(2-bis(1-methylethyl)amino)-alpha-(2-chlorophenyl)-1-piperidinebutanamide 
 
National Institutes of Health

Papers overview

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2004
2004
Smooth muscle cells released by protease from the coronary artery of dogs were cultured in M199 supplemented with 10% fetal calf… Expand
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1991
1991
In the investigation of cellular changes associated with intracellular drug storage, we incubated cultured rabbit aorta muscle… Expand
1990
1990
Cultured cells were found to be highly useful for investigating intracellular storage of amphiphilic compounds using disobutamide… Expand
1989
1989
Disobutamide, a bis tertiary amine (pKa1 = 8.6; pKa2 = 10.2) cationic amphiphilic compound, and a putative cardiac antiarrhythmic… Expand
1989
1989
In the investigation of the dynamic nature of intracellular drug-induced storage disorder associated with clear cytoplasmic… Expand
1988
1988
Analogues of the dibasic antiarrhythmic agent disobutamide (2) were prepared and evaluated for antiarrhythmic efficacy… Expand
1987
1987
Abstract Disobutamide (D), an antiarrhythmic cationic amphiphilic amine (CAA), was withdrawn from clinical testing when clear… Expand
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1986
1986
A subchronic oral toxicity study of disobutamide, a piperidine ring compound with antiarrhythmic activity, was conducted at doses… Expand
1985
1985
Abstract Cellular uptake of disobutamide (D), and clear cytoplasmic vacuoles (CCV) induction by D in cultured rat urinary bladder… Expand
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1980
1980
The synthesis and biological evaluation of a series of alpha, alpha-bis[(dialkylamino)alkyl]phenylacetamides, 2, are presented… Expand