discodermolide

Known as: 2H-Pyran-2-one, 6-(14-((aminocarbonyl)oxy)-2,6,12-trihydroxy-5,7,9,11,13,15-hexamethyl-3,8,16,18-nonadecatetraenyl)tetrahydro-4-hydroxy-3,5-dimethyl-, (3S-(3alpha,4beta,5beta,6alpha(2R*,3Z,5R*,6R*,7S*,8Z,11R*,12S*,13S*,14S*,15R*,16E)))- 
 
National Institutes of Health

Papers overview

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2009
2009
The microtubule cytoskeleton has proven to be an effective target for cancer therapeutics. One class of drugs, known as… (More)
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2006
2006
PURPOSE To evaluate the drug combination of discodermolide and Taxol in human ovarian cancer cells and in an in vivo model of… (More)
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2005
2005
Discodermolide is a microtubule stabilizing agent that suppresses dynamic instability and blocks cells in mitosis. Selection of… (More)
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2004
2004
Discodermolide is a new microtubule-targeted antimitotic drug in Phase I clinical trials that, like paclitaxel, stabilizes… (More)
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2003
2003
We investigated whether discodermolide, a novel antimitotic agent, affects the binding to microtubules of tau protein repeat… (More)
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Highly Cited
2000
Highly Cited
2000
Recently, three natural products have been identified, the epothilones, eleutherobin, and discodermolide, whose mechanism of… (More)
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Highly Cited
1997
Highly Cited
1996
Highly Cited
1996
Computer-assisted structure analysis indicated (+)-discodermolide, a polyhydroxylated alkatetraene lactone marine natural product… (More)
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Review
1993
Review
1993
In summary, discodermolide, a novel, marine-derived compound, is a potent in vitro and in vivo immunosuppressive agent… (More)
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1991
1991
The in vivo immunosuppressive properties of a novel, marine-derived compound, discodermolide, are reported here. Discodermolide… (More)
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