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dinaciclib

Known as: 2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5- a]pyrimidin-5-yl]-, (2S)- 
A pyrazolo[1,5-a]pyrimidine with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Bridged Bicyclo Compounds, HeterocyclicPyridinium Compounds

Narrower (2)

MK-7965SCH 727965
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
PS1075 ANTITUMOR ACTIVITY OF PEMBROLIZUMAB PLUS DINACICLIB IN PATIENTS WITH DIFFUSE LARGE B CELL LYMPHOMA: THE PHASE 1B KEYNOTE-155 STUDY
2018
2018
Abstract 5907: Fulvestrant resistance in estrogen receptor positive breast cancer models is driven by heterogeneous ER independent transcriptional programs
Endocrine therapy is the mainstay of treatment for metastatic estrogen receptor (ER) positive breast cancer. The selective ER… 
2018
2018
Investigating genome engineering of myotonic dystrophy cells and small molecules as potential therapeutic agents
Myotonic dystrophy (DM) is a dominantly inherited multisystem disease. There are 2 types of DM: DM1, caused by a CTG repeat… 
2017
2017
Abstract P3-03-05: PI3K/PDK1 mediates resistance to CDK4/6 inhibitors through dysregulation of S-phase cyclins/cyclin dependent kinases (CDKs)
Background: CDK4/6 inhibitors in combination with antiestrogens are approved for the treatment of ER+ advanced breast cancer… 
2016
2016
Dinaciclib Could Sensitize Myeloma Cells to PARP Inhibition
A new study has shown that dinaciclib disrupted homologous recombination function and led to cell death in multiple myeloma cell… 
2016
2016
Abstract 4688: HPV+ cervical cancer cells are selectively killed by the combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and the cyclin-dependent kinase-9 inhibitor…
Background: Cervical cancer affects more than 520,000 women worldwide yearly, kills over 250,000 and disproportionately affects… 
2016
2016
Abstract 274: Assessing combinations of chemotherapy in alveolar soft part sarcoma cell lines
Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Background: Alveolar Soft Part Sarcoma (ASPS) is… 
2015
2015
The Radiosensitizing Potential of Rigosertib and Dinaciclib in Ewing's Sarcoma Cells
Ewing’s sarcoma is the second most frequent bone cancer. However, it is still a relatively uncommon cancer, with only… 
2012
2012
Targeting CDK in triple-negative breast cancer
UCSF researchers have found that the majority of triple-negative breast cancers have a dysregulated MYC pathway and the group has… 
2011
2011
STOMPING THE GRAPES OF WRATH : NOVEL DRUG RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUS AND SEARCH FOR NEW ANTI-MRSA THERAPEUTICS USING SMALL MOLECULE SCREENS
Chronic lymphocytic leukemia (CLL) characteristically maintains high levels of the anti-apoptotic protein Bcl-2, thus protecting…