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dihydropteroate synthase activity

Known as: dihydropteroate synthetase activity, DHPS activity, dihydropteroate diphosphorylase activity 
Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. [EC… Expand
National Institutes of Health

Papers overview

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2007
2007
A rapid assay for dihydropteroate synthase activity suitable for identification of inhibitors.
The enzymes 6-hydroxymethylpterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) catalyze sequential steps in… Expand
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Review
1998
Review
1998
Use of dapsone in the prevention and treatment of Pneumocystis carinii pneumonia: a review.
  • Walter T. Hughes
  • Clinical infectious diseases : an official…
  • 1998
    • Corpus ID: 11510500
Dapsone, with or without trimethoprim or pyrimethamine, has strong anti-Pneumocystis carinii activity, as demonstrated by in… Expand
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1980
1980
Cell-free dihydropteroate synthetase activity: its use to investigate the relationship between structure and activity of p-aminobenzoic derivatives.
Publisher Summary This chapter discusses the cell-free dihydropteroate synthetase (DHPS) activity. DHPS catalyzes the formation… Expand
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1977
1977
Nutritional requirements for folate compounds and some enzyme activities involved in the folate biosynthesis.
Dihydrofolate synthetase activity is widely distributed in various microorganisms and mushrooms. Animals and microorganisms i.e… Expand
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1976
1976
Nutritional Requirement for 4-Aminobenzoate Caused by Mutation of Dihydropteroate Synthetase
Abstract Aerobacter aerogenes mutant 62-1 AC requires high concentrations of 4-aminobenzoate for growth. The mutant accumulates N… Expand
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1974
1974
Alterations in dihydropteroate synthetase in cell-free extracts of sulfanilamide-resistant Neisseria meningitidis and Neisseria gonorrhoeae.
Extracts from Neisseria meningitidis and N. gonorrhoeae with varying susceptibility to sulfanilamide have been investigated for… Expand
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1973
1973
Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides.
The inhibitory action of various diphenylsulfones and sulfonamides on dihydropteroate synthetase partially purified from… Expand
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1973
1973
A simplified radioassay method of dihydropteroate synthetase activity in Escherichia coli and its application for an inhibition study of p-aminobenzoi acid derivatives.
Abstract A method is described for the determination of the enzymic synthesis of 7,8-dihydropteroic acid in a cell-free system of… Expand
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1973
1973
A simplified radioassay method for dihydropteroate synthetase activity in and its application for an inhibition study of -aminobenzoic acid derivatives
 
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