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dihydrofolic acid binding

Known as: DHF binding, dihydrofolate binding 
Interacting selectively and non-covalently with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro… Expand
National Institutes of Health

Papers overview

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2011
2011
Thermodynamics and solvent effects on substrate and cofactor binding in Escherichia coli chromosomal dihydrofolate reductase.
Chromosomal dihydrofolate reductase from Escherichia coli catalyzes the reduction of dihydrofolate to tetrahydrofolate using… Expand
2008
2008
A Balancing Act between Net Uptake of Water during Dihydrofolate Binding and Net Release of Water upon NADPH Binding in R67 Dihydrofolate Reductase*
R67 dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate using NADPH as a cofactor… Expand
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2005
2005
Escherichia coli FolC Structure Reveals an Unexpected Dihydrofolate Binding Site Providing an Attractive Target for Anti-microbial Therapy*
In some bacteria, such as Escherichia coli, the addition of l-glutamate to dihydropteroate (dihydrofolate synthetase activity… Expand
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1994
1994
Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase.
The function of the hydrophobic residues Leu28, Phe31, Ile50, and Leu54 at the folate binding site in Escherichia coli… Expand
1991
1991
Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
We have applied site-directed mutagenesis methods to change the conserved tryptophan-22 in the substrate binding site of… Expand
1990
1990
Kinetic investigation of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase.
The role of the active site residue phenylalanine-31 (Phe31) for recombinant human dihydrofolate reductase (rHDHFR) has been… Expand
Highly Cited
1988
Highly Cited
1988
Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.
Site-directed mutagenesis was used to generate mutants of recombinant mouse dihydrofolate reductase to test the role of some… Expand
1975
1975
The structure of dihydrofolate reductase. I. Inactivation of bacterial dihydrofolate reductase concomitant with modification of a methionine residue at the active site.
Carboxymethylation by iodoacetate of dihydrofolate reductase from the amethopterin-resistant mutant Streptococcus faecium var… Expand
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1975
1975
The structure of the mutant dihydrofolate reductase from Streptococcus faecium. Amino acid sequence of peptide CNBr 7 and complete sequence of the protein.
The complete amino acid sequence of the mutant dihydrofolate reductase from Streptococcus faecium var. Durans strain A has been… Expand
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