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dihydrofolic acid binding
Known as:
DHF binding
, dihydrofolate binding
Interacting selectively and non-covalently with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Thermodynamics and solvent effects on substrate and cofactor binding in Escherichia coli chromosomal dihydrofolate reductase.
Jordan Grubbs
,
Sharghi Rahmanian
,
+4 authors
E. E. Howell
Biochemistry
2011
Corpus ID: 27118545
Chromosomal dihydrofolate reductase from Escherichia coli catalyzes the reduction of dihydrofolate to tetrahydrofolate using…
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2008
2008
A Balancing Act between Net Uptake of Water during Dihydrofolate Binding and Net Release of Water upon NADPH Binding in R67 Dihydrofolate Reductase*
Shaileja Chopra
,
Russell M Dooling
,
C. G. Horner
,
E. E. Howell
Journal of Biological Chemistry
2008
Corpus ID: 473203
R67 dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate using NADPH as a cofactor…
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2005
2005
Escherichia coli FolC Structure Reveals an Unexpected Dihydrofolate Binding Site Providing an Attractive Target for Anti-microbial Therapy*
M. Mathieu
,
G. Debousker
,
S. Vincent
,
F. Viviani
,
N. Bamas-Jacques
,
V. Mikol
Journal of Biological Chemistry
2005
Corpus ID: 21124039
In some bacteria, such as Escherichia coli, the addition of l-glutamate to dihydropteroate (dihydrofolate synthetase activity…
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1994
1994
Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase.
Z. J. Huang
,
C. Wagner
,
S. Benkovic
Biochemistry
1994
Corpus ID: 36449431
The function of the hydrophobic residues Leu28, Phe31, Ile50, and Leu54 at the folate binding site in Escherichia coli…
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1991
1991
Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
M. Warren
,
K. Brown
,
M. Farnum
,
E. E. Howell
,
J. Kraut
Biochemistry
1991
Corpus ID: 31699612
We have applied site-directed mutagenesis methods to change the conserved tryptophan-22 in the substrate binding site of…
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1990
1990
Kinetic investigation of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase.
J. Tsay
,
J. Appleman
,
+4 authors
Raymond L. Blakley
Biochemistry
1990
Corpus ID: 24424405
The role of the active site residue phenylalanine-31 (Phe31) for recombinant human dihydrofolate reductase (rHDHFR) has been…
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Highly Cited
1988
Highly Cited
1988
Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.
J. Thillet
,
J. Absil
,
S. Stone
,
R. Pictet
The Journal of biological chemistry
1988
Corpus ID: 19596349
Site-directed mutagenesis was used to generate mutants of recombinant mouse dihydrofolate reductase to test the role of some…
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1975
1975
The structure of dihydrofolate reductase. I. Inactivation of bacterial dihydrofolate reductase concomitant with modification of a methionine residue at the active site.
J. Gleisner
,
Raymond L. Blakley
The Journal of biological chemistry
1975
Corpus ID: 12879507
Carboxymethylation by iodoacetate of dihydrofolate reductase from the amethopterin-resistant mutant Streptococcus faecium var…
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1975
1975
The structure of the mutant dihydrofolate reductase from Streptococcus faecium. Amino acid sequence of peptide CNBr 7 and complete sequence of the protein.
D. Peterson
,
J. Gleisner
,
Raymond L. Blakley
The Journal of biological chemistry
1975
Corpus ID: 41505177
The complete amino acid sequence of the mutant dihydrofolate reductase from Streptococcus faecium var. Durans strain A has been…
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