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Although ocular transport and delivery have been well studied, metabolism in the eye is not well documented, even for clinically… Expand SummarySynopsisLevobunolol1 is a potent non-selective β-adrenoceptor blocking agent used for the topical treatment of increased… Expand The objective of this study was to determine which of the five or six corneal epithelial layers was rate-limiting in the corneal… Expand The distribution of ketone reductase activity in the anterior segment tissues of the pigmented rabbit eye and its influence on… Expand The ocular and systemic disposition of levobunolol (LBUN), an antiglaucoma agent, was studied in albino rabbits. After topical… Expand ABSTRACT The ocular β-adrenoceptor antagonist activity of dihydrolevobunolol (DHLB), the major ocular and systemic metabolite of… Expand Binding of 3H-dihydroalprenolol (3H-DHA) to beta-adrenoceptors in homogenates from rat and rabbit lung was homogeneous and of… Expand The metabolism of I‐bunolol, a new f3‐blocking drug, was studied in man after single oral 3‐mg doses of W‐labeled compound… Expand 1. Cell-free preparations from human liver taken at autopsy were used to biosynthesize a metabolite from bunolol. The metabolite… Expand