diflomotecan

Known as: (5R)-5-Ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino(3',4':6,7)indolizino(1,2-b)quinoline-3,15-dione 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2015
012320022015

Papers overview

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2015
2015
The current work integrates cell-cycle dynamics occurring in the bone marrow compartment as a key element in the structure of a… (More)
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2010
2010
In cancer chemotherapy neutropenia is a common dose-limiting toxicity. An ability to predict the neutropenic effects of cytotoxic… (More)
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Review
2009
Review
2009
Diflomotecan, a 10,11-difluoro-homocamptothecin, represents a new promising class of topoisomerase I inhibitors with enhanced… (More)
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2008
2008
Homocamptothecins (hCPTs) are a novel class of topoisomerase I (Top1) inhibitors with enhanced chemical stability compared with… (More)
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2008
2008
Diflomotecan, a homocamptothecin, targets DNA topoisomerase I. Previous clinical trials have demonstrated a variable degree of… (More)
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2007
2007
BACKGROUND BN80915 (diflomotecan) is an E-ring modified camptothecin analogue, which possesses greater lactone stability in… (More)
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2005
2005
Purpose: To determine the maximum tolerated dose (MTD) of intravenous (iv) diflomotecan administered once every 3 weeks, and to… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE The adenosine triphosphate-binding cassette transporter ABCG2 (breast cancer resistance protein [BCRP]) functions as an… (More)
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2004
2004
2045 Background: The E-ring modified camptothecin analogue diflomotecan (BN80915, Ipsen Group) is a new topoisomerase I inhibitor… (More)
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2003
2003
PURPOSE Diflomotecan (BN80915) is an E-ring modified camptothecin analogue that possesses greater lactone stability in plasma… (More)
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