Semantic Scholar uses AI to extract papers important to this topic.
The current work integrates cell-cycle dynamics occurring in the bone marrow compartment as a key element in the structure of a… Expand Diflomotecan, a 10,11-difluoro-homocamptothecin, represents a new promising class of topoisomerase I inhibitors with enhanced… Expand Topoisomerase I (TopoI), an essential enzyme, produces a DNA single strand break allowing DNA relaxation for replication. The… Expand Homocamptothecins (hCPTs) are a novel class of topoisomerase I (Top1) inhibitors with enhanced chemical stability compared with… Expand BACKGROUND
BN80915 (diflomotecan) is an E-ring modified camptothecin analogue, which possesses greater lactone stability in… Expand Two practical, efficient, and scalable asymmetric routes to DE ring fragment 7, a key building block in the synthesis of the… Expand Purpose: To determine the maximum tolerated dose (MTD) of intravenous (iv) diflomotecan administered once every 3 weeks, and to… Expand The adenosine triphosphate–binding cassette transporter ABCG2 (breast cancer resistance protein [BCRP]) functions as an efflux… Expand PURPOSE
Diflomotecan (BN80915) is an E-ring modified camptothecin analogue that possesses greater lactone stability in plasma… Expand Camptothecin analogues and derivatives appear to exert their antitumour activity by binding to topoisomerase I and have shown… Expand