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diflomotecan

Known as: (5R)-5-Ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino(3',4':6,7)indolizino(1,2-b)quinoline-3,15-dione 
 
National Institutes of Health

Papers overview

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2015
2015
The current work integrates cell-cycle dynamics occurring in the bone marrow compartment as a key element in the structure of a… Expand
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Review
2008
Review
2008
Topoisomerase I (TopoI), an essential enzyme, produces a DNA single strand break allowing DNA relaxation for replication. The… Expand
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2008
2008
Homocamptothecins (hCPTs) are a novel class of topoisomerase I (Top1) inhibitors with enhanced chemical stability compared with… Expand
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2008
2008
PurposeDiflomotecan, a homocamptothecin, targets DNA topoisomerase I. Previous clinical trials have demonstrated a variable… Expand
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2007
2007
BACKGROUND BN80915 (diflomotecan) is an E-ring modified camptothecin analogue, which possesses greater lactone stability in… Expand
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2006
2006
Two practical, efficient, and scalable asymmetric routes to DE ring fragment 7, a key building block in the synthesis of the… Expand
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2005
2005
Purpose: To determine the maximum tolerated dose (MTD) of intravenous (iv) diflomotecan administered once every 3 weeks, and to… Expand
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2005
2005
An international meeting on 'New Drugs in Cancer Therapy' was held at the National Tumor Institute of Naples, on 17-18 June 2004… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE The adenosine triphosphate-binding cassette transporter ABCG2 (breast cancer resistance protein [BCRP]) functions as an… Expand
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2003
2003
PURPOSE Diflomotecan (BN80915) is an E-ring modified camptothecin analogue that possesses greater lactone stability in plasma… Expand
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