diazonamide A

A total synthesis of the marine natural product diazonamide A (1) has been accomplished. This work features a highly… Expand

Diazonamide A (1, Figure 1) is a marine-derived natural product with potent antimitotic activity and an unusual architecture.[1… Expand

During the course of studies on the synthesis of diazonamide A 1, an unusual O-aryl into C-aryl rearrangement was discovered that… Expand

As an especially unique target for chemical synthesis, diazonamide A has the potential to be constructed through a plethora of… Expand

With the addition of a tenth ring, the exchange of an oxygen atom for a nitrogen in the heart of the molecule, and a different… Expand

A brief introduction into the chemistry of diazonamide A (1) is followed by first-generation sequences to access the originally… Expand

The marine ascidian Diazona angulata was the source organism for the complex cytotoxic peptide diazonamide A. The molecular… Expand

[Reaction in text]The indole-bisoxazole fragment of diazonamide A was prepared by a Chan-type rearrangement of a tertiary amide… Expand

[reaction: see text] Two complementary strategies for the synthesis of the diazonamide A bisaryl quaternary center are described… Expand

[formula: see text] The synthesis of a 3-oxazol-5-yl-indole-4-triflate is described, featuring a Schölkopf reaction to prepare… Expand