diazonamide A
National Institutes of Health
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A total synthesis of the marine natural product diazonamide A (1) has been accomplished. This work features a highly…
Diazonamide A (1, Figure 1) is a marine-derived natural product with potent antimitotic activity and an unusual architecture.[1…
The complex structure of the marine metabolic diazonamide A comprises a dichlorinated indole bis-oxazole heteroaromatic fragment…
During the course of studies on the synthesis of diazonamide A 1, an unusual O-aryl into C-aryl rearrangement was discovered that…
With the addition of a tenth ring, the exchange of an oxygen atom for a nitrogen in the heart of the molecule, and a different…
As an especially unique target for chemical synthesis, diazonamide A has the potential to be constructed through a plethora of…
A brief introduction into the chemistry of diazonamide A (1) is followed by first-generation sequences to access the originally…
The marine ascidian Diazona angulata was the source organism for the complex cytotoxic peptide diazonamide A. The molecular…
[reaction: see text] Two complementary strategies for the synthesis of the diazonamide A bisaryl quaternary center are described…