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desosamine

National Institutes of Health

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Broader (1)

Amino Sugars

Papers overview

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2012
2012
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives.
Structural factors behind erm macrolide resistance were studied through synthesis of new macrolide derivates possessing truncated… 
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2009
2009
Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine.
D-desosamine (1) is a 3-(N,N-dimethylamino)-3,4,6-trideoxyhexose found in a number of macrolide antibiotics including methymycin… 
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2009
2009
Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC from Streptomyces venezuelae *
The cytochrome P-450 PikC from Streptomyces venezuelae exhibits significant substrate tolerance and performs multiple… 
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Highly Cited
2005
Highly Cited
2005
Production of the Potent Antibacterial Polyketide Erythromycin C in Escherichia coli
ABSTRACT An Escherichia coli strain capable of producing the potent antibiotic erythromycin C (Ery C) was developed by expressing… 
2005
2005
TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene.
Analysis of the tylosin gene cluster in Streptomyces fradiae uncovered an ORF, tyl1a, homologous to a hexose 3,4-isomerase found… 
2002
2002
Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
Methylation catalyzed by an S-adenosylmethionine- (AdoMet-) dependent methyltransferase is an effective means to alter the… 
Highly Cited
2001
Highly Cited
2001
Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity.
BACKGROUND Combinatorial biosynthesis techniques using polyketide synthases (PKSs) in heterologous host organisms have enabled… 
Highly Cited
1999
Highly Cited
1999
Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety.
[formula: see text] The appended sugars in macrolide antibiotics are indispensable to the biological activities of these… 
Review
1998
Review
1998
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
In a survey of microbial systems capable of generating unusual metabolite structural variability, Streptomyces venezuelae ATCC… 
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Highly Cited
1997
Highly Cited
1997
Analysis of seven genes from the eryAI –eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea
Abstract The gene cluster (ery) governing the biosynthesis of the macrolide antibiotic erythromycin A by Saccharopolyspora… 
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