desosamine

 
National Institutes of Health

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Amino Sugars

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2012
2012
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives.
Structural factors behind erm macrolide resistance were studied through synthesis of new macrolide derivates possessing truncated… (More)
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2009
2009
Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine.
D-desosamine (1) is a 3-(N,N-dimethylamino)-3,4,6-trideoxyhexose found in a number of macrolide antibiotics including methymycin… (More)
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2009
2009
Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae.
The cytochrome P-450 PikC from Streptomyces venezuelae exhibits significant substrate tolerance and performs multiple… (More)
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2007
2007
Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.
Desosamine is a 3-(dimethylamino)-3,4,6-trideoxyhexose found, for example, in such macrolide antibiotics as erthyromycin… (More)
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2005
2005
Production of the potent antibacterial polyketide erythromycin C in Escherichia coli.
An Escherichia coli strain capable of producing the potent antibiotic erythromycin C (Ery C) was developed by expressing 17 new… (More)
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2005
2005
TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene.
Analysis of the tylosin gene cluster in Streptomyces fradiae uncovered an ORF, tyl1a, homologous to a hexose 3,4-isomerase found… (More)
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2002
2002
Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
Methylation catalyzed by an S-adenosylmethionine- (AdoMet-) dependent methyltransferase is an effective means to alter the… (More)
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2001
2001
Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity.
BACKGROUND Combinatorial biosynthesis techniques using polyketide synthases (PKSs) in heterologous host organisms have enabled… (More)
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1999
1999
Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety.
[formula: see text] The appended sugars in macrolide antibiotics are indispensable to the biological activities of these… (More)
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1999
1999
Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on…
The potential of 14/15 membered macrolides to cause phospholipidosis has been prospectively assessed, and structure-effects… (More)
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