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desosamine

National Institutes of Health

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Broader (1)

Amino Sugars

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Synthesis of D-Desosamine and Analogs by Rapid Assembly of 3-Amino Sugars.
D-Desosamine is synthesized in 4 steps from methyl vinyl ketone and sodium nitrite. The key step in this chromatography-free… 
2013
2013
Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities.
2012
2012
Synthesis and antibacterial activity of desosamine-modified macrolide derivatives.
2008
2008
Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.
D-Desosamine, or 3-(dimethylamino)-3,4,6-trideoxyglucose, is an unusual sugar found on the macrolide antibiotic erythromycin, and… 
2008
2008
Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces venezuelae YJ003-OTBP3.
Two sugar biosynthetic cassette plasmids were used to direct the biosynthesis of a deoxyaminosugar. The pOTBP1 plasmid containing… 
2007
2007
Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.
Desosamine is a 3-(dimethylamino)-3,4,6-trideoxyhexose found, for example, in such macrolide antibiotics as erthyromycin… 
2006
2006
Systematic approach to understanding macrolide-ribosome interactions: NMR and modeling studies of oleandomycin and its derivatives.
The three-dimensional structures of oleandomycin (1) and its derivatives oleandomycin-9-oxime (2) and 10,11-anhydrooleandomycin… 
2002
2002
Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.
Methylation catalyzed by an S-adenosylmethionine- (AdoMet-) dependent methyltransferase is an effective means to alter the… 
Highly Cited
1999
Highly Cited
1999
Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety.
[formula: see text] The appended sugars in macrolide antibiotics are indispensable to the biological activities of these… 
1995
1995
Conformational change due to esterification of hydroxy groups in erythromycin A and its major metabolite: analysis of these derivatives with different biological properties using NMR and molecular…
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