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desmethylselegiline

Known as: demethyl-deprenyl-DMD, di-N-propargylamphetamine, N-desmethyl-selegiline 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AmphetaminesMonoamine Oxidase Inhibitors

Narrower (1)

desmethylselegiline, (-)-isomer

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Quantitative analysis of desmethylselegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term selegiline medication.
Hair and plasma from patients on long-term selegiline medication were analyzed to evaluate the relationships between plasma and… 
Review
2003
Review
2003
Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease.
Nitric oxide (NO), in excess, behaves as a cytotoxic substance mediating the pathological processes that cause neurodegeneration… 
Highly Cited
2001
Highly Cited
2001
Effects of an Inhibitor of Poly(ADP-Ribose) Polymerase, Desmethylselegiline, Trientine, and Lipoic Acid in Transgenic ALS Mice
The development of transgenic mouse models of amyotrophic lateral sclerosis (ALS) allows the testing of neuroprotective agents… 
2001
2001
Simultaneous determination of selegiline-N-oxide, a new indicator for selegiline administration, and other metabolites in urine by high-performance liquid chromatography-electrospray ionization mass…
Highly Cited
2000
Highly Cited
2000
Etiology, pathogenesis, and experimental treatment of retinitis pigmentosa.
The paper provides an interdisciplinary evaluation of the etiology, pathogenesis, and experimental treatments of retinitis… 
Highly Cited
2000
Highly Cited
2000
Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes.
We investigated the effects of selegiline and desmethylselegiline on synthesis of neurotrophic factors in cultured mouse… 
2000
2000
Multiple-Dose Pharmacokinetics of Selegiline and Desmethylselegiline Suggest Saturable Tissue Binding
The goal of this study was to examine the multiple-dose pharmacokinetics of selegiline and its metabolites desmethylselegiline, l… 
1999
1999
Stereoselective analyses of selegiline metabolites: possible urinary markers for selegiline therapy.
Highly Cited
1998
Highly Cited
1998
Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion.
Oxidative stress is thought to play an important role in the pathogenesis of Parkinson's disease (PD). Glutathione (GSH), a major… 
Highly Cited
1997
Highly Cited
1997
l‐(−)‐Desmethylselegiline, a Metabolite of Selegiline [l‐(−)‐Deprenyl], Protects Mesencephalic Dopamine Neurons from Excitotoxicity In Vitro
Abstract: Selegiline [l‐(−)‐deprenyl], a monoamine oxidase B inhibitor, has been used in the treatment of Parkinson's disease as… 
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