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desmethylcyproheptadine

National Institutes of Health

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Cyproheptadine
analogs & derivatives

Papers overview

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1993
1993
Pharmacokinetics of cyproheptadine and its metabolites in rats.
To investigate the pharmacokinetics of cyproheptadine (CPH) and its metabolites, the plasma concentration and urinary excretion… 
1991
1991
Interactions of diabetogenic compounds: cyproheptadine and alloxan.
1988
1988
Evidence that drug metabolites are involved in cyproheptadine-induced loss of pancreatic insulin.
The effects of pretreatment with inhibitors of drug metabolism on the biotransformation of cyproheptadine (CPH) and the ability… 
1987
1987
Metabolism and disposition of cyproheptadine and desmethylcyproheptadine in pregnant and fetal rats.
The tissue distribution of unchanged drug and metabolites in pregnant rats was studied following oral administration of… 
1986
1986
Susceptibility of fetal rat endocrine pancreas to the diabetogenic action of cyproheptadine.
1985
1985
The mechanism of action of cyproheptadine on prolactin release by cultured anterior pituitary cells.
1983
1983
Effect of cyproheptadine, desmethylcyproheptadine, gamma-amino-butyric acid and sodium valproate on adrenocorticotrophin secretion by cultured pituitary tumour cells from three patients with Nelson's…
The effects of cyproheptadine, desmethylcyproheptadine, serotonin, gamma-amino-butyric acid (GABA) and sodium valproate were… 
1983
1983
Cyproheptadine and desmethylcyproheptadine directly inhibit the release of adrenocorticotrophin and beta-lipotrophin/beta-endorphin activity from the neurointermediate lobe of the rat pituitary gland…
Cyproheptadine and its metabolite desmethylcyproheptadine were shown to suppress directly the release of adrenocorticotrophin… 
1974
1974
Identification of desmethylcyproheptadine-10,11-epoxide and other cyproheptadine metabolites isolated from rat urine.
Desmethylcyproheptadine-10,11-epoxide, cyproheptadine-10,11-epoxide, and desmethylcyproheptadine were identified in rat urine… 
1973
1973
Structure-activity relationships in drug-induced pancreatic islet cell toxicity.
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