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desferrithiocin

Known as: 2-(3'-hydroxypyrid-2'-yl)-4-methylthiazoline-4-carboxylic acid, 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-, monosodium salt, (S)- 
 
National Institutes of Health

Papers overview

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2010
2010
The current solution to iron-mediated damage in transfusional iron overload disorders is decorporation of excess unmanaged metal… Expand
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Review
2004
Review
2004
Iron chelators may be of value as therapeutic agents in the treatment of cancer. They may act by depleting iron, a necessary… Expand
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Review
2003
Review
2003
Successful treatment of beta-thalassemia requires two key elements: blood transfusion and iron chelation. Regular blood… Expand
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2002
2002
Desferrithiocin (DFT) is an orally effective Fe chelator, with a similar high affinity and selectivity for Fe to desferrioxamine… Expand
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1994
1994
The (S)-desferrithiocin (DFT) skeleton is shown to be a useful pharmacophore on which to design orally effective iron chelators… Expand
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1993
1993
A comparative study of the iron-clearing properties of subcutaneously administered desferrioxamine B (DFO) with those of orally… Expand
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1992
1992
The efficacy and toxicity of the siderophore desferrithiocin (DFT), which has shown potential application in iron chelation… Expand
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Highly Cited
1991
Highly Cited
1991
Desferrithiocin, a novel microbial siderophore isolated from cultures of Streptomyces antibioticus DSM 1865, and a number of its… Expand
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Highly Cited
1987
Highly Cited
1987
The mechanism by which cigarette smoking and asbestos exposure synergistically increase the incidence of lung cancer is unknown… Expand
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Highly Cited
1986
Highly Cited
1986
Because oxygen-centered free radicals are involved in cell-mediated immune responses, we examined the possibility that these… Expand
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