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desethyloxybutynin
Known as:
Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, 4-(ethylamino)-2-butynyl ester
, N-desethyloxybutynin
, deethyloxybutynin
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Mandelic Acids
Narrower (1)
desethyloxybutynin hydrochloride
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Transdermal Oxybutynin
C. M. Baldwin
,
G. Keating
Drugs
2012
Corpus ID: 33534909
Abstract▴ Oxybutynin inhibits contraction of the detrusor muscle in the overactive bladder by binding to muscarinic M3 receptors…
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2009
2009
Urinary Incontinence: Oxybutynin topical gel for overactive bladder
C. Chapple
Nature Reviews Urology
2009
Corpus ID: 1825420
Antimuscarinic drugs are the first-line treatment for overactive bladder. However, traditional formulations are associated with a…
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2009
2009
The evolution of transdermal therapy for overactive bladder
P. Sand
Current urology reports
2009
Corpus ID: 27615958
Oxybutynin chloride has been effectively used for treating overactive bladder syndrome for more than three decades. The evolution…
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2007
2007
Stereoselective pharmacokinetics of oxybutynin and N-desethyloxybutynin in vitro and in vivo
H. Mizushima
,
K. Takanaka
,
K. Abe
,
I. Fukazawa
,
H. Ishizuka
Xenobiotica; the fate of foreign compounds in…
2007
Corpus ID: 26040520
In vitro studies and the multiple applications of an oxybutynin (OXY) transdermal delivery system to Japanese healthy volunteers…
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Highly Cited
2004
Highly Cited
2004
Pharmacokinetics of the R- and S-Enantiomers of Oxybutynin and N-Desethyloxybutynin Following Oral and Transdermal Administration of the Racemate in Healthy Volunteers
R. Zobrist
,
Bernhard Schmid
,
A. Feick
,
D. Quan
,
S. Sanders
Pharmaceutical Research
2004
Corpus ID: 8004795
AbstractPurpose. To characterize the enantiomers of oxybutynin (OXY) and N-desethyloxybutynin (DEO) following transdermal and…
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Highly Cited
2004
Highly Cited
2004
Pharmacokinetics and Metabolism of Transdermal Oxybutynin: In Vitro and in Vivo Performance of a Novel Delivery System
R. Zobrist
,
D. Quan
,
Heather Thomas
,
S. Stanworth
,
S. Sanders
Pharmaceutical Research
2004
Corpus ID: 10064029
AbstractPurpose. The purpose of this work was to characterize in vitro/in vivo delivery and pharmacokinetics of oxybutynin (OXY…
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2002
2002
Effect of muscarinic antagonists on micturition pressure measured by cystometry in normal, conscious rats.
A. Modiri
,
P. Alberts
,
P. Gillberg
Urology
2002
Corpus ID: 43819665
2002
2002
Binding study of desethyloxybutynin using high-performance frontal analysis method.
Akimasa Shibukaw
,
Y. Yoshikawa
,
Tomoko Kimura
,
Yukihiro Kuroda
,
T. Nakagawa
,
I. Wainer
Journal of chromatography. B, Analytical…
2002
Corpus ID: 4553322
Highly Cited
2001
Highly Cited
2001
Effect of OROS controlled-release delivery on the pharmacokinetics and pharmacodynamics of oxybutynin chloride.
G. Sathyan
,
M. Chancellor
,
S. Gupta
British journal of clinical pharmacology
2001
Corpus ID: 39821353
UNLABELLED Aims : Dry mouth is a common side-effect seen with immediate-release oxybutynin (IR-Oxy). Ditropan XL [(Oxy-XL), a…
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1981
1981
Metabolism of Oxybutynin: establishment of desethyloxybutynin and oxybutynin N-oxide formation in rat liver preparation using deuterium substitution and gas chromatographic mass spectrometric…
B. Lindeke
,
G. Hallström
,
C. Johansson
,
Ō. Ericsson
,
L. Olsson
,
S. Strömberg
Biomedical mass spectrometry
1981
Corpus ID: 13607737
Oxybutynin is rapidly metabolized in rat liver microsomes. Two major primary oxidation products were identified as N-desethyl…
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