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desethyloxybutynin

Known as: Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, 4-(ethylamino)-2-butynyl ester, N-desethyloxybutynin, deethyloxybutynin 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Mandelic Acids

Narrower (1)

desethyloxybutynin hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Urinary Incontinence: Oxybutynin topical gel for overactive bladder
  • C. Chapple
  • Nature Reviews Urology
  • 2009
    • Corpus ID: 1825420
Antimuscarinic drugs are the first-line treatment for overactive bladder. However, traditional formulations are associated with a… Expand
  • table 1
2008
2008
Enantioselective analysis of oxybutynin and N-desethyloxybutynin with application to an in vitro biotransformation study.
An enantioselective method using liquid-phase microextraction (LPME) followed by HPLC analysis was developed for the… Expand
2007
2007
Stereoselective pharmacokinetics of oxybutynin and N-desethyloxybutynin in vitro and in vivo
In vitro studies and the multiple applications of an oxybutynin (OXY) transdermal delivery system to Japanese healthy volunteers… Expand
Highly Cited
2004
Highly Cited
2004
Pharmacokinetics of the R- and S-Enantiomers of Oxybutynin and N-Desethyloxybutynin Following Oral and Transdermal Administration of the Racemate in Healthy Volunteers
AbstractPurpose. To characterize the enantiomers of oxybutynin (OXY) and N-desethyloxybutynin (DEO) following transdermal and… Expand
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Highly Cited
2004
Highly Cited
2004
Pharmacokinetics and Metabolism of Transdermal Oxybutynin: In Vitro and in Vivo Performance of a Novel Delivery System
AbstractPurpose. The purpose of this work was to characterize in vitro/in vivo delivery and pharmacokinetics of oxybutynin (OXY… Expand
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2003
2003
Sensitive determination of oxybutynin and desethyloxybutynin in dog plasma by LC-ESI/MS/MS.
  • Hohyun Kim, S. Han
  • Journal of pharmaceutical and biomedical analysis
  • 2003
    • Corpus ID: 25686407
A sensitive and selective liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed for the… Expand
2002
2002
Binding study of desethyloxybutynin using high-performance frontal analysis method.
Plasma protein binding of N-desethyloxybytynin (DEOXY), a major active metabolite of oxybutynin (OXY), was investigated… Expand
2002
2002
Effect of muscarinic antagonists on micturition pressure measured by cystometry in normal, conscious rats.
OBJECTIVES To establish an in vivo model to screen new muscarinic antagonists for the treatment of overactive urinary bladder and… Expand
Highly Cited
2001
Highly Cited
2001
Effect of OROS controlled-release delivery on the pharmacokinetics and pharmacodynamics of oxybutynin chloride.
UNLABELLED Aims : Dry mouth is a common side-effect seen with immediate-release oxybutynin (IR-Oxy). Ditropan XL [(Oxy-XL), a… Expand
1981
1981
Metabolism of Oxybutynin: establishment of desethyloxybutynin and oxybutynin N-oxide formation in rat liver preparation using deuterium substitution and gas chromatographic mass spectrometric…
Oxybutynin is rapidly metabolized in rat liver microsomes. Two major primary oxidation products were identified as N-desethyl… Expand
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