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desethylamiodarone

Known as: Methanone, (2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)-, N-desethylamiodarone, deethylamiodarone 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Amiodarone
Desethylamiodarone:SCnc:Pt:Ser/Plas:Qnanalogs & derivatives

Papers overview

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2000
2000
Effects of amiodarone on heart cells.
To the Editor: We read with interest the article by Ide et al.1 The authors showed that amiodarone protects cardiac myocytes… 
Highly Cited
1987
Highly Cited
1987
Comparative electrophysiologic effects of intravenous amiodarone and desethylamiodarone in dogs: evidence for clinically relevant activity of the metabolite.
It has been suggested that some of the effects of long-term amiodarone therapy may be due to accumulation of a metabolite… 
Highly Cited
1986
Highly Cited
1986
Effects of Amiodarone and Desethylamiodarone on Rabbit Myocardial β‐Adrenoceptors and Serum Thyroid Hormones—Absence of Relationship to Serum and Myocardial Drug Concentrations
Summary: The antiadrenergic actions of amiodarone (Am) are well known but its effect and that of its metabolite… 
1986
1986
Effects of Desethylamiodarone on Thyroid Hormone Metabolism in Rats: Comparison with the Effects of Amiodarone
Abstract Desethylamiodarone is the principal metabolite of amiodarone. Amiodarone is a class III antiarrhythmic agent, which acts… 
1986
1986
Digoxin–Desethylamiodarone Interaction in the Rat: Comparison with the Effects of Amiodarone
Summary: We have shown that there is a pharmacokinetic interaction between amiodarone and digoxin that results in an increase in… 
1986
1986
Peripheral neutrophil inclusions in amiodarone treated patients.
In 14 patients receiving chronic amiodarone therapy the appearance of multilamellar inclusion bodies in peripheral blood… 
1985
1985
Pharmacokinetics, antiarrhythmic effects, and tissue concentrations of amiodarone and desethylamiodarone in dogs with acute coronary artery occlusion.
A single bolus of 5 or 40 mg/Kg of amiodarone was injected 24 hours after inducing coronary artery occlusion in the closed-chest… 
1984
1984
Tissue extraction of amiodarone and N-desethylamiodarone in man after a single oral dose.
The hepatic extraction of amiodarone and N-desethylamiodarone has been investigated in seven patients following catheterization… 
1983
1983
High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in small tissue samples after enzymatic digestion.
A method is described for the measurement of amiodarone and desethylamiodarone in small tissue samples. With the exception of fat… 
1982
1982
High‐Performance Liquid Chromatographic Measurement of Amiodarone and Its Desethyl Metabolite: Methodology and Preliminary Observations
A high-performance liquid chromatographic technique is described for the measurement of amiodarone and its desethyl metabolite in… 
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