dehydroapratoxin A

Apratoxin A is a cytotoxic natural product that prevents the biogenesis of secretory and membrane proteins. Biochemically… Expand

Cultivation of the marine cyanobacterium Moorea producens, collected from the Nabq Mangroves in the Gulf of Aqaba (Red Sea), led… Expand

The tropical marine cyanobacterium, Moorea bouillonii, has gained recent attention as a rich source of bioactive natural products… Expand

The first asymmetric total synthesis of the marine natural product apratoxin D, a highly potent inhibitor of H-460 human lung… Expand

Apratoxins are cytotoxic marine natural products that prevent cotranslational translocation early in the secretory pathway. We… Expand

Apratoxin A is a potent cytotoxic marine natural product that rapidly inhibits signal transducer and activator of transcription… Expand

Promoting the degradation of Hsp90 client proteins by inhibiting Hsp90, an important protein chaperone, has been shown to be a… Expand

Cancer cell toxicity-guided fractionation of extracts of the Papua New Guinea marine cyanobacteria Lyngbya majuscula and Lyngbya… Expand

The cyanobacterial metabolite apratoxin A (1) demonstrates potent cytotoxicity against tumor cell lines by a hitherto unknown… Expand

A novel total synthesis of apratoxin A is described, with key steps including the assembly of its ketide segment through a D… Expand