FAQ

dechloroethylifosfamide

Known as: 2-DClIF, 2-dechloroethylifosfamide, 2-amino-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazophosphorine-2-o-xide 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2014
01219832014

Related topics

Related topics

1 relation

Broader (1)

Ifosfamide

Related mentions per year

Related mentions per year

1961-2018
1960198020002020
dechloroethylifosfamide
Ifosfamide

Papers overview

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2015
2015
Multi-residue enantiomeric analysis of human and veterinary pharmaceuticals and their metabolites in environmental samples by chiral liquid chromatography coupled with tandem mass spectrometry…
Enantiomeric profiling of chiral pharmacologically active compounds (PACs) in the environment has hardly been investigated. This… (More)
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2004
2004
Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity
Repeated administration of agents (e.g., cancer chemotherapy) that can cause drug-induced nephrotoxicity may lead to acute or… (More)
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2000
2000
Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites.
Nephrotoxicity is a limiting factor in the use of ifosfamide in children. Despite the co-administration of uroprotective agents… (More)
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1998
1998
The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study.
In a randomized cross-over trial, 11 patients received ifosfamide (IFOS) in 21-day cycles, which alternated between 3 g m(-2) x… (More)
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1997
1997
Urinary excretion of ifosfamide, 4-hydroxyifosfamide, 3- and 2-dechloroethylifosfamide, mesna, and dimesna in patients on fractionated intravenous ifosfamide and concomitant mesna therapy
 The oxazaphosphorine antineoplastic ifosfamide (IF) is metabolized by two different initial pathways: ring oxidation… (More)
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1996
1996
Nuclear magnetic resonance and high-performance liquid chromatography-nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide.
A combination of high-resolution nuclear magnetic resonance (NMR) and high-performance liquid chromatography (HPLC)-NMR… (More)
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1993
1993
Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy
The initial metabolism of the oxazaphosphorine cytostatic ifosfamide (IF) consists of two different pathways: ring oxidation at… (More)
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1993
1993
Determination of the urinary excretion of ifosfamide and its phosphorated metabolites by phosphorus-31 nuclear magnetic resonance spectroscopy
Phosphorus-31 nuclear magnetic resonance spectroscopy was used to analyze urine samples obtained from patients treated with… (More)
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1992
1992
A new approach to the study of ifosfamide metabolism by the analysis of human body fluids with 31P nuclear magnetic resonance spectroscopy.
[31P] nuclear magnetic resonance spectroscopy was used to analyze body fluids from patients treated with ifosfamide (IF). This… (More)
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1983
1983
Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide.
Isophosphoramide mustard was synthesized and was found to demonstrate activity essentially comparable to cyclophosphamide and… (More)
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