death-inducing signaling complex location

Known as: death-inducing signalling complex, death receptor-induced signaling complex location, death receptor-induced signalling complex 
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
The death-inducing signaling complex (DISC) formed by the death receptor Fas, the adaptor protein FADD and caspase-8 mediates the… (More)
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Highly Cited
2005
Highly Cited
2005
c-FLIPs (c-FLICE inhibitory proteins) play an essential role in regulation of death receptor-induced apoptosis. Multiple splice… (More)
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Highly Cited
2004
Highly Cited
2004
The molecular regulation of the recruitment of initial signaling complexes at the TNF-R1 is poorly defined. We demonstrate here… (More)
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Highly Cited
2004
Highly Cited
2004
Neutrophils are abundant, short-lived leukocytes, and their death by apoptosis is central to hemostasis and the resolution of… (More)
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Highly Cited
2003
Highly Cited
2003
Resveratrol, a polyphenol found in grape skin and various other food products, may function as a cancer chemopreventive agent for… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of the caspase cascade is a pivotal step in apoptosis and can occur via death adaptor-mediated homo-oligomerization of… (More)
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Highly Cited
1998
Highly Cited
1998
The assembly of the CD-95 (Fas/Apo-1) receptor death-inducing signaling complex occurs in a hierarchical manner; the death domain… (More)
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Highly Cited
1997
Highly Cited
1997
Upon activation, the apoptosis-inducing cell membrane receptor CD95 (APO-1/Fas) recruits a set of intracellular signaling… (More)
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Highly Cited
1997
Highly Cited
1997
Induction of apoptosis by the cell surface receptor CD95 (APO-1/Fas) has been shown to involve activation of a family of cysteine… (More)
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Highly Cited
1995
Highly Cited
1995
APO-1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces apoptosis upon receptor oligomerization. In… (More)
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