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death-inducing signaling complex assembly

Known as: death-inducing signalling complex assembly, DISC formation, DD-mediated complex assembly 
A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

extrinsic apoptotic signaling pathway
negative regulation of death-inducing signaling complex assembly

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Visualization of fas-mediated death-inducing signaling complex formation by immunoprecipitation.
The prototypical death receptor Fas (also known as CD95 or Apo-1) plays an essential role in the maintenance of lymphocyte… Expand
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2013
2013
Survivin-3B potentiates immune escape in cancer but also inhibits the toxicity of cancer chemotherapy.
Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significant factor in cancer… Expand
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2013
2013
Molecular and Cellular Pathobiology Survivin-3 B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy
Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significant factor in cancer… Expand
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Highly Cited
2011
Highly Cited
2011
Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells.
The glycosyltransferase, ST6Gal-I, adds sialic acid in an α2-6 linkage to the N-glycans of membrane and secreted glycoproteins… Expand
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2008
2008
Regulating Vav1 phosphorylation by the SHP-1 tyrosine phosphatase is a fine-tuning mechanism for the negative regulation of DISC formation and Fas-mediated cell death signaling
The actin cytoskeleton association is required for caspase 8-independent Fas/CD95 receptor internalization, a critical step for… Expand
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Highly Cited
2007
Highly Cited
2007
Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts.
Cytokines such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in colon cancer cells… Expand
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2007
2007
Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death.
We investigated the relationship between the resistance to the proapoptotic action of tumor necrosis factor-related apoptosis… Expand
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Highly Cited
2005
Highly Cited
2005
Caspase-dependent and -independent activation of acid sphingomyelinase signaling.
Recent evidence suggests clustering of plasma membrane rafts into ceramide-enriched platforms serves as a transmembrane signaling… Expand
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Highly Cited
2004
Highly Cited
2004
CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.
We investigated the membrane localization of CD95 in type I and type II cells, which differ in their ability to recruit and… Expand
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2001
2001
Fas aggregation does not correlate with Fas-mediated apoptosis.
Cross-linking of cell surface Fas molecules by Fas ligand or by agonistic anti-Fas Abs induces cell death by apoptosis. We found… Expand
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