FAQ

death-inducing signaling complex assembly

Known as: death-inducing signalling complex assembly, DISC formation, DD-mediated complex assembly 
A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2017
02420012017

Related topics

Related topics

2 relations

Broader (1)

extrinsic apoptotic signaling pathway
negative regulation of death-inducing signaling complex assembly

Related mentions per year

Related mentions per year

1975-2018
197019801990200020102020
death-inducing signaling complex assembly
negative regulation of death-inducing signaling complex assembly
extrinsic apoptotic signaling pathway

Papers overview

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2013
2013
Visualization of fas-mediated death-inducing signaling complex formation by immunoprecipitation.
The prototypical death receptor Fas (also known as CD95 or Apo-1) plays an essential role in the maintenance of lymphocyte… (More)
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2013
2013
Structural insight for the roles of fas death domain binding to FADD and oligomerization degree of the Fas-FADD complex in the death-inducing signaling complex formation: a computational study.
Fas binding to Fas-associated death domain (FADD) activates FADD-caspase-8 binding to form death-inducing signaling complex (DISC… (More)
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2011
2011
Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent with cancer-selective… (More)
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Highly Cited
2008
Highly Cited
2008
Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1.
Cigarette smoke-induced cell death contributes to the pathogenesis of chronic obstructive pulmonary disease, though the relative… (More)
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2008
2008
Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia.
Clonal T-cell expansion in patients with T-large-granular lymphocyte (LGL) leukemia occurs by an undefined mechanism that may be… (More)
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2007
2007
Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death.
We investigated the relationship between the resistance to the proapoptotic action of tumor necrosis factor-related apoptosis… (More)
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2007
2007
Adriamycin-Resistant Carcinoma Cells to TRAIL-Mediated Silencing of Prion Protein Sensitizes Breast
We investigated the relationship between the resistance to the proapoptotic action of tumor necrosis factor–related apoptosis… (More)
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Highly Cited
2005
Highly Cited
2005
Caspase-dependent and -independent activation of acid sphingomyelinase signaling.
Recent evidence suggests clustering of plasma membrane rafts into ceramide-enriched platforms serves as a transmembrane signaling… (More)
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2004
2004
CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.
We investigated the membrane localization of CD95 in type I and type II cells, which differ in their ability to recruit and… (More)
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2001
2001
Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis.
Activation of protein kinase C (PKC) triggers cellular signals that inhibit Fas/CD95-induced cell death in Jurkat T-cells by… (More)
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