deacetylase activity

Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. [GOC:jl]
National Institutes of Health

Papers overview

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2013
2013
The SIRT6 deacetylase is a key regulator of mammalian genome stability, metabolism and lifespan. Previous studies indicated that… (More)
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Highly Cited
2011
Highly Cited
2011
The protein deacetylase, sirtuin 1 (SIRT1), is a proposed master regulator of exercise-induced mitochondrial biogenesis in… (More)
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Highly Cited
2010
Highly Cited
2010
SIRT1 (Sirtuin type 1), a mammalian orthologue of yeast SIR2 (silent information regulator 2), has been shown to mediate a… (More)
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Highly Cited
2008
Highly Cited
2008
Colorectal cancer is the most abundant cause of cancer mortality in the Western world. Nutrition and the microbial flora are… (More)
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2008
Highly Cited
2008
Resveratrol may protect against metabolic disease through activating SIRT1 deacetylase. Because we have recently defined AMPK… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Growing evidence suggests that sirtuins, a family of seven distinct NAD-dependent enzymes, are involved in the… (More)
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2007
Highly Cited
2007
SIRT1 is the closest mammalian homologue of yeast SIR2, an important ageing regulator that prolongs lifespan in response to… (More)
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Highly Cited
2005
Highly Cited
2005
Robust activation of poly(ADP-ribose) polymerase-1 (PARP) by oxidative stress has been implicated as a major cause of caspase… (More)
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2003
Highly Cited
2003
The use of histone deacetylase (HDAC) inhibitors has revealed an essential role for deacetylation in transcription of IFN… (More)
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Highly Cited
2003
Highly Cited
2003
Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) is a known regulatory transcription factor that has been shown to interact… (More)
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