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deacetoxyvinzolidine

Known as: 3''-(beta-chloroethyl)-2'',4''-dioxo-3,5''-spirooxazolidino-4-deacetoxyvinblastine, KAR 2, KAR-2 
National Institutes of Health

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2 relations

Broader (1)

Vinblastine
analogs & derivatives

Papers overview

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2013
2013
Effects of the semisynthetic bis-indole derivative KAR-2 on store-operated calcium entry in human neutrophils.
2009
2009
Unique pharmacology of KAR-2, a potential anti-cancer agent: absorption modelling and selective mitotic spindle targeting.
2008
2008
Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy
Cancer continues to be one of the major health and socio-economic problems worldwide, despite considerable efforts to improve its… 
2004
2004
THE STRUCTURE OF CALMODULIN’S COMPLEX WITH KAR-2: A NOVEL MODE OF BINDING EXPLAINS THE DRUG’S UNIQUE PHARMACOLOGY
is a potent antimicrotubular agent that arrests mitosis in cancer cells without significant toxic side effect. In this study we… 
2004
2004
Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid
2001
2001
A new bis-indole, KARs, induces selective M arrest with specific spindle aberration in neuroblastoma cell line SH-SY5Y.
KARs, new semisynthetic antitumor bis-indole derivatives, were found to be inhibitors of tubulin polymerization with lower… 
1997
1997
Interaction of a new bis‐indol derivative, KAR‐2 with tubulin and its antimitotic activity
KAR‐2 (3″‐(β‐chloroethyl)‐2″,4″‐dioxo‐3,5″‐spiro‐oxazolidino‐4‐deacetoxy‐vinblastine), is a bis‐indol derivative; catharantine is… 
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