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daunorubicin biosynthetic process

Known as: daunorubicin biosynthesis, daunorubicin anabolism, daunorubicin synthesis 
The chemical reactions and pathways resulting in the formation of daunorubicin. [GOC:TermGenie, GOC:yaf, PMID:7601857, UniPathway:UPA00054]
National Institutes of Health

Papers overview

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2004
2004
One of the final steps in the biosynthesis of the widely used anti-tumor drug daunorubicin in Streptomyces peucetius is the… Expand
2000
2000
The dnrO gene is located adjacent to and divergently transcribed from the response regulator gene, dnrN, that activates the… Expand
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Highly Cited
1999
Highly Cited
1999
The starter unit used in the biosynthesis of daunorubicin is propionyl coenzyme A (CoA) rather than acetyl-CoA, which is used in… Expand
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Highly Cited
1996
Highly Cited
1996
The DnrI protein, essential for the biosynthesis of daunorubicin in Streptomyces peucetius, was purified almost to homogeneity… Expand
1996
1996
DnrN, a protein essential for the transcription of the dnrI gene, which in turn activates transcription of the daunorubicin… Expand
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Highly Cited
1995
Highly Cited
1995
Sequence analysis of the Streptomyces peucetius daunorubicin biosynthetic gene cluster revealed a partial (dnrQ) and two complete… Expand
Highly Cited
1995
Highly Cited
1995
The dnrQS genes from the daunorubicin producer Streptomyces peucetius were characterized by DNA sequencing, complementation… Expand
Highly Cited
1995
Highly Cited
1995
We previously proposed that the adjacent dnrIJ genes represent a two-component regulatory system controlling daunorubicin… Expand
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Highly Cited
1995
Highly Cited
1995
Sequence analysis of the dnrR2 locus from the cluster of daunorubicin biosynthesis genes in Streptomyces peucetius ATCC 29050 has… Expand
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Highly Cited
1990
Highly Cited
1990
Genes for the biosynthesis of daunorubicin (daunomycin) and doxorubicin (adriamycin), important antitumor drugs, were cloned from… Expand