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dasatinib
Known as:
BMS dasatinib
, Dasatinib [Chemical/Ingredient]
, N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
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An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth…
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National Institutes of Health
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Related topics
Related topics
25 relations
Broader (2)
Antineoplastic Agents
Protein Kinase Inhibitors
Narrower (3)
BMS 354825
Sprycel
dasatinib anhydrous
CSK protein, human
Ephrin Type-A Receptor 2, human
Fusion Proteins, bcr-abl
In Blood
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Dasatinib-letrozole gets split verdict.
Cancer Discovery
2014
Corpus ID: 37746319
Although the addition of dasatinib to letrozole improved progression-free survival in postmenopausal women with estrogen receptor…
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2011
2011
Fibrosis, regeneration, and aging: playing chess with evolution.
V. Torres
,
E. Leof
Journal of the American Society of Nephrology
2011
Corpus ID: 46740265
In this issue of JASN , Iyoda et al. [1][1] report that administration of nilotinib, a second-generation inhibitor of cellular…
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2010
2010
Hemorrhagic colonic ulcers caused by dasatinib for chronic myelogenous leukemia
Y. Ono
,
T. Mori
,
+5 authors
S. Okamoto
International journal of hematology
2010
Corpus ID: 29013317
Dasatinib, a multi-kinase inhibitor that is active against BCR-ABL1 and SRC family kinases, has been reported to exert notable…
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2009
2009
Inibidores de tirosino quinase na leucemia mieloide crônica
Nei R. Lopes
,
M.T.C.L. Abreu
2009
Corpus ID: 72306936
A leucemia mieloide cronica (LMC) e uma neoplasia da medula ossea originada da translocacao entre os cromossomos 9 e 22 t(9:22…
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2009
2009
Dasatinib induces a response in chronic lymphocytic leukemia.
V. Pitini
,
C. Arrigo
,
G. Altavilla
Blood
2009
Corpus ID: 206874070
To the editor: Dasatinib is a novel oral multitargeted kinase inhibitor of Bcr-Abl and Src family widely used for the treatment…
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2008
2008
Dasatinib or high-dose imatinib for patients with chronic myelogenous leukemia chronic-phase (CML-CP) resistant to standard- dose imatinib: 2-year follow-up data from START-R
P. Rousselot
,
T. Facon
,
R. Paquette
,
E. Bleickardt
,
D. Dejardin
,
H. Kantarjian
2008
Corpus ID: 73935177
7012 Background: Resistance to imatinib is a well-recognized problem in CML-CP. Dasatinib is 325-fold more potent than imatinib…
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2008
2008
Nilotinib in chronic myelogenous leukemia patients who failed prior imatinib and dasatinib therapy: Updated results of an open-label phase II study
E. Abruzzese
,
G. Alimena
,
+6 authors
F. Giles
2008
Corpus ID: 68870727
7055 Background: Few therapeutic options exist for patients (pts) with Philadelphia chromosome-positive (Ph+) chronic myelogenous…
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2008
2008
Effect of dasatinib on bone metabolism in multiple myeloma
T. Wildes
,
Elizabeth Procknow
,
K. Weilbaecher
,
R. Vij
2008
Corpus ID: 75201063
8568 Background: Src kinases play a major role in osteoclast function. In vitro, small molecule inhibitors of Src block…
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2006
2006
Dasatinib : Treatment of leukemia treatment of solid tumors Bcr-Abl and Src kinase inhibitor
J. Mcintyre
,
J. Castaǹer
,
M. Bayes
2006
Corpus ID: 79010927
Chronic myelogenous leukemia (CML) results from a single mutagenic event leading to acquisition of the Philadelphia chromosome…
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2005
2005
Dasatinib (BMS-354825): A Multi-Targeted Kinase Inhibitor with Activity Against Multiple Myeloma.
Qingwei Deng
,
N. Mitsiades
,
+9 authors
C. Mitsiades
2005
Corpus ID: 90030989
The genetic heterogeneity of multiple myeloma (MM) and the evolution of the disease as it progresses result in a multiplicity of…
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