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darinaparsin

Known as: clarinaparsin, DMAs(III)SG, S-(dimethylarsino)glutathione 
A small-molecule organic arsenical with potential antineoplastic activity. Although the exact mechanism of action is unclear, darinaparsin, a highly… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Chronic kidney disease is characterized by interstitial fibrosis and proliferation of scar-secreting myofibroblasts, ultimately… Expand
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Review
2014
Review
2014
Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic detoxification in many species is the… Expand
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2012
2012
PURPOSE Hypoxia is an important characteristic of the solid tumor microenvironment and constitutes a barrier for effective… Expand
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2012
2012
Darinaparsin is a novel organic arsenic compound that is being developed to improve the efficacy and therapeutic index of arsenic… Expand
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2009
2009
PURPOSE Darinaparsin, an organic arsenic, targets essential cell survival pathways. We determined the dose-limiting toxicity (DLT… Expand
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2009
2009
Here, we report on the organic arsenical darinaparsin (ZIO-101, S-dimethylarsino-glutathione) and its anti-myeloma activity… Expand
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2009
2009
SummaryBackground Darinaparsin is a novel organic arsenic that reaches higher intracellular concentration with decreased toxicity… Expand
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2006
2006
BACKGROUND AND PURPOSE Although inorganic arsenite (As(III)) is toxic in humans, it has recently emerged as an effective… Expand
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2005
2005
Arsenicals are known to be toxic and carcinogenic in humans. Inorganic arsenicals are enzymatically methylated to… Expand
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2005
2005
The reaction of dimethylarsinic acid (DMAV) with hydrogen sulfide (H2S) is of biological significance and may be implicated in… Expand
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