dactylolide
National Institutes of Health
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Zampanolide and dactylolide are microtubule-stabilizing polyketides possessing potent cytotoxicity towards a variety of cancer…
Whole chromosomal instability (CIN), manifested as unequal chromosome distribution during cell division, is a distinguishing…
Summary Bestmann ylide [(triphenylphosphoranylidene)ketene] acts as a chemical linchpin that links nucleophilic entities, such as…
Zampanolide and its structural relative dactylolide are promising new tubulin-assembly agents with the potential to become new…
The solution conformation behavior of the macrolide core of microtubule-stabilizing agents (-)-zampanolide and (-)-dactylolide…
The development of an approach leading to the total synthesis of dactylolide is described. The key features of this route include…
The total synthesis of (-)-dactylolide and formal synthesis of (-)-zampanolide via target oriented beta-C-glycoside formation is…
[reaction: see text] The development of an approach leading to the total synthesis of dactylolide is described. The key features…