cytochrome P450 activity

Known as: cytochrome P450 
OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically… (More)

Topic mentions per year

Topic mentions per year

1968-2018
020040019682018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
CONTEXT Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary syndromes and following percutaneous… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
The human clearance of proton pump inhibitors (PPIs) of the substituted benzimidazole class is conducted primarily by the hepatic… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
Is this relevant?
Highly Cited
2003
Highly Cited
2003
We used human liver microsomes (HLMs) and recombinant cytochromes P450 (P450s) to identify the routes of efavirenz metabolism and… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Insecticide resistance is one of the most widespread genetic changes caused by human activity, but we still understand little… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The purpose of this study was to establish bupropion (BUP) hydroxylation as a selective in vitro marker of cytochrome P450 (CYP… (More)
  • figure 1
  • figure 2
  • figure 5
  • figure 6
  • table 1
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Four polymorphic human cytochrome P450 (CYP) 1B1 allelic variants, namely Arg48,Ala119,Leu432,Asn453, Arg48,Ser119,Leu432,Asn453… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Cytochrome P450 (P450) 3A4 is the most abundant human P450 and oxidizes a diversity of substrates, including various drugs… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
The 4-hydroxy metabolite of 17 beta-estradiol (E2) has been implicated in the carcinogenicity of this hormone. Previous studies… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
The O-dealkylations of ethoxyresorufin and pentoxyresorufin are widely used activity probes for measuring the cytochrome P450… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
When the cDNA encoding bovine microsomal 17 alpha-hydroxylase cytochrome P450 (P45017 alpha) containing modifications within the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?