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cytochrome P-450 CYP2C subfamily

Known as: CYP2C, cytochrome P-450 2C subfamily 
 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Monkeys are widely used as a primate model to study drug metabolism because they generally show a metabolic pattern similar to… Expand
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2002
2002
Ecteinascidin 743 (ET743, NSC648766) is a marine natural product with potent in vivo activity in human xenograft models… Expand
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Review
2001
Review
2001
  • J. Goldstein
  • British journal of clinical pharmacology
  • 2001
  • Corpus ID: 26190851
The human CYP2Cs are an important subfamily of P450 enzymes that metabolize approximately 20% of clinically used drugs. There are… Expand
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Highly Cited
2001
Highly Cited
2001
The expression of three cytochromes P450 (CYP3A4, CYP2C9, and CYP2B6) was investigated in primary human hepatocyte cultures… Expand
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Highly Cited
1999
Highly Cited
1999
Troglitazone, a new oral antidiabetic drug, is reported to be mostly metabolized to its conjugates and not to be oxidized by… Expand
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Review
1998
Review
1998
Sex-dependent differences in xenobiotic metabolism have been most extensively studied in the rat. Because sex-dependent… Expand
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Highly Cited
1998
Highly Cited
1998
The cytochromes P450 are a large family of haemoproteins which have a major role in the oxidative metabolism of a wide range of… Expand
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Highly Cited
1997
Highly Cited
1997
Experiments were performed in vivo and in vitro to date the onset of hepatic CYP2C isoforms and CYP2C-dependent activities during… Expand
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Highly Cited
1996
Highly Cited
1996
Human first-trimester placentas were screened for the expression of xenobiotic-metabolizing cytochrome P450 (CYP) genes. mRNAs of… Expand
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Highly Cited
1993
Highly Cited
1993
The nature of the enzyme(s) catalyzing the major metabolic pathway of diclofenac, 4'-hydroxylation, was investigated in human… Expand
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