cytochrome P-450 CYP2C subfamily

Known as: CYP2C, cytochrome P-450 2C subfamily 
 
National Institutes of Health

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Review
2010
Review
2010
Cardiovascular diseases (CVDs) remain the leading cause of death in the developed countries. Taking into account the mounting… (More)
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Review
2009
Review
2009
In humans, four members of the CYP2C subfamily (CYP2C8, CYP2C9, CYP2C18, and CYP2C19) metabolize more than 20% of all therapeutic… (More)
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2006
2006
Monkeys are widely used as a primate model to study drug metabolism because they generally show a metabolic pattern similar to… (More)
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2002
2002
Ecteinascidin 743 (ET743, NSC648766) is a marine natural product with potent in vivo activity in human xenograft models… (More)
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Highly Cited
2002
Highly Cited
2002
Although CYP2C8, CYP2C9, and CYP2C19 play an important role in drug biotransformation, factors influencing the expression and… (More)
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2001
2001
The expression of three cytochromes P450 (CYP3A4, CYP2C9, and CYP2B6) was investigated in primary human hepatocyte cultures… (More)
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Highly Cited
1999
Highly Cited
1999
Troglitazone, a new oral antidiabetic drug, is reported to be mostly metabolized to its conjugates and not to be oxidized by… (More)
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Highly Cited
1997
Highly Cited
1997
Experiments were performed in vivo and in vitro to date the onset of hepatic CYP2C isoforms and CYP2C-dependent activities during… (More)
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Highly Cited
1996
Highly Cited
1996
Human first-trimester placentas were screened for the expression of xenobiotic-metabolizing cytochrome P450 (CYP) genes. mRNAs of… (More)
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Highly Cited
1993
Highly Cited
1993
The nature of the enzyme(s) catalyzing the major metabolic pathway of diclofenac, 4'-hydroxylation, was investigated in human… (More)
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