cyclin D1-CDK4 complex

Known as: cyclin D1-CDK4 complex location 
A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2014
01219982014

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Nucleolar GTP-binding protein (NGP-1) is overexpressed in various cancers and proliferating cells, but the functional… (More)
Is this relevant?
Review
2014
Review
2014
Familial melanoma accounts for approximately a tenth of all melanoma cases. The most commonly known melanoma susceptibility gene… (More)
Is this relevant?
Review
2011
Review
2011
The c-myc is a proto-oncogene that manifests aberrant expression at high frequencies in most types of human cancer. C-myc gene… (More)
Is this relevant?
2009
2009
Embryonic stem cells are immortalized cells whose proliferation rate is comparable to that of carcinogenic cells. To study the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2004
2004
Although clotrimazole (CLT), an antifungal drug, inhibits tumor cell proliferation and angiogenesis, its clinical application is… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 7
Is this relevant?
2003
2003
Cyclin D-dependent kinases phosphorylate the retinoblastoma (Rb) protein and play a critical role in neuronal cell cycle control… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2002
2002
Stimulation of the breast cancer-derived MCF-7S cell line with insulin-like growth factor I (IGF-I; 20 ng/ml) leads to enhanced… (More)
Is this relevant?
2002
2002
Deregulation of D-type cyclin-dependent kinases (CDK4 and 6) is widely observed in various human cancers, illustrating their… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
BACKGROUND Two genes have been implicated in the development of cutaneous malignant melanoma (CMM). CDK4 (the gene encoding… (More)
  • table 1
  • table 2
  • table 3
Is this relevant?
1998
1998
Cyclin D1, which functionally competes with the tumor suppressor genes retinoblastoma (Rb) and p16INK4, is widely recognized as… (More)
Is this relevant?