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coumermycin

Known as: Coumermycin A1, [(3R,4S,5R)-5-Hydroxy-6-[2-hydroxy-3-[[4-[[2-hydroxy-7-[(3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-4-oxochromen-3-yl]carbamoyl]-3-methyl-1H-pyrrole-2-carbonyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60… Expand
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Highly Cited
1998
Highly Cited
1998
Interleukin‐10 (IL‐10) limits inflammatory responses by inhibiting macrophage activation. In macrophages, IL‐10 activates Stat1… Expand
Highly Cited
1996
Highly Cited
1996
THE Raf-1 serine/threonine kinase is a key component of the MAP kinase cascade1–3, regulating both proliferation and commitment… Expand
Highly Cited
1990
Highly Cited
1990
The ability to enter intestinal epithelial cells is an essential virulence factor of salmonellae. We have previously cloned a… Expand
Highly Cited
1982
Highly Cited
1982
Novobiocin, coumermycin A1, and clorobiocin, structurally related compounds that antagonize the B subunit of the essential… Expand
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Highly Cited
1978
Highly Cited
1978
Abstract Folded chromosomes isolated from Escherichia coli strains after treatment with coumermycin A 1 in vivo , an inhibitor of… Expand
Highly Cited
1978
Highly Cited
1978
Escherichia coli DNA gyrase catalyzes negative supercoiling of closed duplex DNA at the expense of ATP. Two additional activities… Expand
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Highly Cited
1977
Highly Cited
1977
ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but… Expand
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Highly Cited
1976
Highly Cited
1976
Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently… Expand
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