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coumermycin

Known as: Coumermycin A1, [(3R,4S,5R)-5-Hydroxy-6-[2-hydroxy-3-[[4-[[2-hydroxy-7-[(3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-4-oxochromen-3-yl]carbamoyl]-3-methyl-1H-pyrrole-2-carbonyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

AminocoumarinsTopoisomerase II Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.
Highly Cited
2004
Highly Cited
2004
In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach.
Highly Cited
2000
Highly Cited
2000
Identification of the Coumermycin A1Biosynthetic Gene Cluster of Streptomyces rishiriensisDSM 40489
ABSTRACT The biosynthetic gene cluster of the aminocoumarin antibiotic coumermycin A1 was cloned by screening of a cosmid library… 
Highly Cited
1991
Highly Cited
1991
An unusual mechanism for resistance to the antibiotic coumermycin A1.
Bacterial DNA gyrases are type II topoisomerases made up of two A subunits and two B subunits. Coumarins are carbohydrate… 
Highly Cited
1987
Highly Cited
1987
Fusions of the Escherichia coli gyrA and gyrB control regions to the galactokinase gene are inducible by coumermycin treatment
We have previously shown that the genes encoding the two subunits of Escherichia coli DNA gyrase are regulated in a manner which… 
Highly Cited
1984
Highly Cited
1984
The purification and characterization of DNA topoisomerases I and II of the yeast Saccharomyces cerevisiae.
Highly Cited
1983
Highly Cited
1983
The effect of bacterial DNA gyrase inhibitors on DNA synthesis in mammalian mitochondria.
Highly Cited
1982
Highly Cited
1982
DNA gyrase is a host factor required for transposition of Tn5
1981
1981
DNA-damaging agents and DNA-synthesis inhibitors induce luminescence in dark variants of luminous bacteria.
Highly Cited
1976
Highly Cited
1976
Coumermycin A1: A preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterization.
Coumermycin A1, an antibiotic related to novobiocin, inhibited nucleic acid synthesis in intact Escherichia coli with replication… 
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