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We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is… Expand BACKGROUND
Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60… Expand Interleukin‐10 (IL‐10) limits inflammatory responses by inhibiting macrophage activation. In macrophages, IL‐10 activates Stat1… Expand THE Raf-1 serine/threonine kinase is a key component of the MAP kinase cascade1–3, regulating both proliferation and commitment… Expand The ability to enter intestinal epithelial cells is an essential virulence factor of salmonellae. We have previously cloned a… Expand Novobiocin, coumermycin A1, and clorobiocin, structurally related compounds that antagonize the B subunit of the essential… Expand Abstract Folded chromosomes isolated from Escherichia coli strains after treatment with coumermycin A 1 in vivo , an inhibitor of… Expand Escherichia coli DNA gyrase catalyzes negative supercoiling of closed duplex DNA at the expense of ATP. Two additional activities… Expand ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but… Expand Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently… Expand