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coumermycin

Known as: Coumermycin A1, [(3R,4S,5R)-5-Hydroxy-6-[2-hydroxy-3-[[4-[[2-hydroxy-7-[(3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-4-oxochromen-3-yl]carbamoyl]-3-methyl-1H-pyrrole-2-carbonyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

AminocoumarinsTopoisomerase II Inhibitors

Papers overview

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1987
1987
Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice
Herpes simplex virus type 1 was reactivated from the trigeminal ganglia of latently infected mice in a quantitative and time… 
1985
1985
Mutations affecting gyrase in Haemophilus influenzae
Mutants separately resistant to novobiocin, coumermycin, nalidixic acid, and oxolinic acid contained gyrase activity as measured… 
1984
1984
Effect of coumermycin on influenza A virus replicative cycle.
Coumermycin A1, a Novobiocin related antibiotic, has been tested in vivo and in vitro for its activity on Influenza A viruses. In… 
Highly Cited
1983
Highly Cited
1983
Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling
Oxolinic acid reduced RNA synthesis rates whether chromosome supercoiling decreased, increased, or remained unchanged. Thus… 
1982
1982
DNA dependence and inhibition by novobiocin and coumermycin of the nucleolar adenosine triphosphatase (ATPase) of human fibroblasts.
We have recently demonstrated by electron microscopic cytochemical methods that unfixed human fibroblasts exhibit intense MG2… 
1979
1979
Search for a DNA gyrase in mammalian mitochondria.
Incorporation of labeled deoxynucleoside triphosphates into mtDNA by isolated rat liver mitochondria has been shown previously to… 
Highly Cited
1976
Highly Cited
1976
Coumermycin A1: A preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterization.
Coumermycin A1, an antibiotic related to novobiocin, inhibited nucleic acid synthesis in intact Escherichia coli with replication… 
Review
1971
Review
1971
Structure-activity relationships in chemically modified coumermycin
Abstract 
1970
1970
The Effect of Coumermycin A1on the Meningococcal Carrier State
Meningococci are extremely sensitive to coumermycin A1in vitro. The results of a controlled double-blind study in Naval recruits… 
1969
1969
In Vitro Activity of Coumermycin A1
The in vitro activity of coumermycin A1 was compared with that of novobiocin, ampicillin, and minocycline. Coumermycin was found… 
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