combretastatin

Known as: 3-Hydroxy-4-methoxy-alpha-(3,4,5-trimethoxyphenyl)benzeneethanol, Combretastatin, (+-) 
A stilbenoid phenol, originally isolated from the bark of the African bush willow tree Combretum caffrum, with vascular disrupting and antineoplastic… (More)
National Institutes of Health

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Highly Cited
2002
Highly Cited
2002
Combretastatin A-4-phosphate (CA-4-P) is a tubulin-binding compound currently in clinical trial as a tumor vascular-targeting… (More)
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2000
2000
The di-sodium phosphate pro-drug of combretastatin-A4(combA-4P) is undergoing Phase 1 clinical trial in the USA and UK. Its… (More)
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Highly Cited
1999
Highly Cited
1999
The potential for tumor vascular-targeting by using the tubulin destabilizing agent disodium combretastatin A-4 3-0-phosphate (CA… (More)
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Highly Cited
1997
Highly Cited
1997
Selective induction of vascular damage within tumors represents an emerging approach to cancer treatment. Histological studies… (More)
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Highly Cited
1995
Highly Cited
1995
Combretastatin A-4 (1a), the principal cancer cell growth-inhibitory constituent of the Zulu medicinal plant Combretum caffrum… (More)
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Highly Cited
1995
Highly Cited
1995
A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise… (More)
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1995
1995
The antineoplastic constituents of Combretum caffrum (Eckl. and Zeyh) Kuntze (Combretaceae family), a species indigenous to South… (More)
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Highly Cited
1989
Highly Cited
1989
The African treeCombretum caffrum (Combretaceae) has been found to contain a powerful inhibitor of tubulin polymerization (IC502… (More)
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Highly Cited
1989
Highly Cited
1989
Combretastatin A-4 (CS-A4), 3,4,5-trimethoxy-3'-hydroxy-4'-methoxy-(Z)-stilbene, and combretastatin A-2 (CS-A2), 3,4… (More)
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1988
1988
Combretastatin, an antineoplastic and antimitotic agent, was isolated from the bark of Combretum caffrum [Can. J. Chem. 60: 1374… (More)
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