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cocaine metabolic process

Known as: cocaine metabolism 
The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2017
024619792017

Papers overview

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2011
2011
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
Cocaine is a widely abused drug without a U.S. Food and Drug Administration-approved medication. There is a recognized, promising… (More)
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2008
2008
Most efficient cocaine hydrolase designed by virtual screening of transition states.
Cocaine is recognized as the most reinforcing of all drugs of abuse. There is no anticocaine medication available. The disastrous… (More)
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2004
2004
Sex differences in cocaine-induced behavioral responses, pharmacokinetics, and monoamine levels.
Female rats display a more robust behavioral response to acute cocaine administration than do male rats. However, a clear… (More)
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2003
2003
Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels.
Previous studies showed that prolonged access to cocaine or heroin self-administration (long access, or LgA) produces an… (More)
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2003
2003
Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme
We present the first crystal structures of a human protein bound to analogs of cocaine and heroin. Human carboxylesterase 1 (hCE1… (More)
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2001
2001
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
Butyrylcholinesterase (BChE) is important in cocaine metabolism, but it hydrolyzes (-)-cocaine only one-two thousandth as fast as… (More)
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2000
2000
Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression.
Cocaine N-demethylation to norcocaine was studied in human liver microsomes of different ages. Norcocaine was formed at a… (More)
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2000
2000
Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized female rats.
To determine whether cocaine-induced behavioral alterations are modulated by ovarian hormones, ovariectomized rats were randomly… (More)
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1999
1999
Estrous cycle differences in cocaine-induced stereotypic and locomotor behaviors in Fischer rats.
This study was conducted to characterize female behavioral response to acute 'binge' pattern cocaine administration (15 mg kg(-1… (More)
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1999
1999
Effects of sex and gonadectomy on cocaine metabolism in the rat.
The purpose of the current study is to determine whether sex differences in metabolism of cocaine (COC) exist that could… (More)
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