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clavam

National Institutes of Health

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Clavulanic Acids

Papers overview

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2009
2009
Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence.
Tazobactam, sulbactam, and clavulanic acid are the only beta-lactamase inhibitors in clinical use. Comparative inhibitory… 
Highly Cited
2005
Highly Cited
2005
The enzymology of clavam and carbapenem biosynthesis.
The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including beta-amino acid and… 
2004
2004
Streptomyces clavuligerus Has a Second Copy of the Proclavaminate Amidinohydrolase Gene
ABSTRACT Past genetic studies have indicated that the genes encoding early enzymes of clavulanic acid biosynthesis may be… 
2002
2002
Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.
During biosynthesis of the clinically used beta-lactamase inhibitor clavulanic acid, one of the three steps catalysed by… 
2001
2001
Applications of Gene Replacement Technology toStreptomyces clavuligerus Strain Development for Clavulanic Acid Production
ABSTRACT Cephamycin C production was blocked in wild-type cultures of the clavulanic acid-producing organism Streptomyces… 
Review
2000
Review
2000
Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics.
Clavulanic acid is a secondary metabolite produced by Streptomyces clavuligerus. It possesses a clavam structure and a… 
Review
1999
Review
1999
Class A beta-lactamases--enzyme-inhibitor interactions and resistance.
Beta-Lactamases of Ambler's Class A are the most commonly encountered mechanism of bacterial resistance to beta-lactam… 
1995
1995
Purification and Characterization of Clavaminate Synthase from Streptomyces antibioticus
Clavaminate synthase (CS), a key enzyme in the clavulanic acid biosynthetic pathway, has been purified to electrophoretic… 
1991
1991
Beta-lactam antifungals. II. Enantiocontrolled synthesis of (2R,5S)-2-hydroxymethyl-1-carbapenam, the carba-analog of a clavam antifungal.
(2R,5S)-2-Hydroxymethyl-1-carbapenam (3), the carba-analog of an antifungal beta-lactam (2R,5S)-2-(hydroxymethyl)calvam (1), was… 
1983
1983
Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. III. Absolute stereochemistry.
The complete stereostructure of the new antibiotic Ro 22-5417 has been established as 3-[(3S,5S)-7-oxo-1-aza-4-oxabicyclo[3.2.O… 
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