ciclopirox

Known as: Ciclopiroxum, 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone, ciclopirox [Chemical/Ingredient] 
A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding… (More)
National Institutes of Health

Related topics

Related topics

18 relations

Broader (2)

Antifungal AgentsPyridones

Narrower (5)

BatrafenCiclopirox olamineDafnegin-CSCHOE 296
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Cutaneous CandidiasisDecreased Protein Synthesis [PE]HypersensitivityOnychomycosis
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Papers overview

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2013
2013
Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity.
Ciclopirox, an antifungal agent commonly used for the dermatologic treatment of mycoses, has been shown recently to have… (More)
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2009
2009
Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A
Eukaryotic translation initiation factor eIF5A has been implicated in HIV-1 replication. This protein contains the apparently… (More)
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2009
2009
Iontophoretically enhanced ciclopirox delivery into and across human nail plate.
Transungual delivery of antifungal drugs is hindered by the low permeability of human nail plates, and as such, repeated dosing… (More)
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Review
2008
Review
2008
Update in Antifungal Therapy of Dermatophytosis
Treatment of dermatophyte infection involves primarily oral and/or topical formulations of azoles or allylamines, particularly… (More)
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2005
2005
Combination of oral terbinafine and topical ciclopirox compared to oral terbinafine for the treatment of onychomycosis.
BACKGROUND Treatment of onychomycosis has recently been enhanced by the introduction of combination therapies. OBJECTIVE To… (More)
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2005
2005
Ciclopirox protects mitochondria from hydrogen peroxide toxicity.
1 The mitochondrial respiratory chain produces reactive oxygen species (ROS) during normal electron transport. Despite producing… (More)
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Highly Cited
2003
Highly Cited
2003
In vitro susceptibility testing of ciclopirox, terbinafine, ketoconazole and itraconazole against dermatophytes and nondermatophytes, and in vitro evaluation of combination antifungal activity.
BACKGROUND With the development of newer antifungal agents with activity against both yeasts and filamentous fungi, there is an… (More)
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2002
2002
The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro.
The hypusine biosynthetic steps represent novel targets for intervention in cell proliferation. Hypusine is a rare amino acid… (More)
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Review
2000
Review
2000
Dermatopharmacology of ciclopirox nail lacquer topical solution 8% in the treatment of onychomycosis.
Ciclopirox is a synthetic hydroxypyridone antifungal agent. In contrast to the azoles, glucuronidation is the main metabolic… (More)
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Highly Cited
1996
Highly Cited
1996
Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support.
In the present study, we tested whether apoptotic neuronal death caused by withdrawal of trophic support might be prevented by… (More)
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