choline O-acetyltransferase activity

Known as: CHOACTase activity, choline acetylase activity, acetyl-CoA:choline O-acetyltransferase activity 
Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. [EC:2.3.1.6, RHEA:18824]
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of markers within cholinergic basal… (More)
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Highly Cited
2006
Highly Cited
2006
A comparative approach to the differences between systemic toxicity and developmental neurotoxicity of organophosphates is… (More)
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Highly Cited
2002
Highly Cited
2002
In Alzheimer's disease (AD), loss of cortical and hippocampal choline acetyltransferase (ChAT) activity has been correlated with… (More)
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Highly Cited
1998
Highly Cited
1998
Despite extensive adverse publicity, tobacco use continues in approximately 25% of all pregnancies in the United States… (More)
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Highly Cited
1997
Highly Cited
1997
Emerging evidence suggests that the p75 neurotrophin receptor (p75NTR) mediates cell death; however, it is not known whether… (More)
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Highly Cited
1990
Highly Cited
1990
Ultrastructural studies of biopsied cortical tissue from the right frontal lobe of 8 patients with mild to moderate Alzheimer's… (More)
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Highly Cited
1988
Highly Cited
1988
We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the… (More)
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Highly Cited
1985
Highly Cited
1985
Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the… (More)
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Highly Cited
1982
Highly Cited
1982
We have examined the choline acetyltransferase [CAT] activity in autopsy samples of frontal and temporal lobe cortex from 47… (More)
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Highly Cited
1978
Highly Cited
1978
Necropsy brain tissue from normal (control) patients and patients with depression and dementia was examined for activities of… (More)
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