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choline O-acetyltransferase activity

Known as: CHOACTase activity, choline acetylase activity, acetyl-CoA:choline O-acetyltransferase activity 
Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. [EC:2.3.1.6, RHEA:18824]
National Institutes of Health

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2 relations
negative regulation of choline O-acetyltransferase activitypositive regulation of choline O-acetyltransferase activity

Papers overview

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Review
2008
Review
2008
Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
Alzheimer’s disease (AD) is characterized by a progressive phenotypic downregulation of markers within cholinergic basal… 
Highly Cited
2005
Highly Cited
2005
Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease
Brain‐derived neurotrophic factor (BDNF) is critical for the function and survival of neurons that degenerate in the late stage… 
Highly Cited
2002
Highly Cited
2002
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
In Alzheimer's disease (AD), loss of cortical and hippocampal choline acetyltransferase (ChAT) activity has been correlated with… 
Highly Cited
1985
Highly Cited
1985
Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation.
Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the… 
Highly Cited
1985
Highly Cited
1985
Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats
Highly Cited
1985
Highly Cited
1985
Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.
Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support… 
Highly Cited
1985
Highly Cited
1985
Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons
Highly Cited
1982
Highly Cited
1982
Alzheimer's disease Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities
Highly Cited
1978
Highly Cited
1978
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
Necropsy brain tissue from normal (control) patients and patients with depression and dementia was examined for activities of… 
Highly Cited
1969
Highly Cited
1969
Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.
1. The methods for the assay of choline acetyltransferase were based on the reaction between labelled acetyl-CoA and unlabelled… 
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