chlorofusin

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2015
012320012015

Papers overview

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2015
2015
Previous studies on the natural product chlorofusin have shown that the full peptide and azaphilone structure are required for… (More)
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2009
2009
An efficient and convergent solution-phase synthesis of the cyclic peptide of the natural product chlorofusin, a reported… (More)
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Review
2009
Review
2009
Inhibitors of key protein-protein interactions are emerging as exciting therapeutic targets for the treatment of cancer. One such… (More)
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2008
2008
Chlorofusin is a recently isolated, naturally occurring inhibitor of p53-MDM2 complex formation whose structure is composed of a… (More)
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2007
2007
We report an efficient and versatile solid-phase synthesis through which two series of chlorofusin analogues, one bearing varying… (More)
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2007
2007
Chlorofusin (1, Figure 1A) was isolated from the fungal strain Microdochium caespitosum and found to disrupt the MDM2-p53… (More)
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2003
2003
The first solid-phase synthesis of the chlorofusin peptide is described. The synthesis involved side-chain immobilization of N… (More)
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2003
2003
The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves… (More)
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2001
2001
Wild-type p53 plays a crucial role in the prevention of cancer. Since dysfunction of p53 can be caused by increased levels of the… (More)
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