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chlorofusin

National Institutes of Health

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Cyclic Peptides

Papers overview

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2008
2008
Chlorofusin: Total synthesis, stereochemical reassignment, determination of absolute configuration, and the synthesis of seven chromophore analogs
2007
2007
Total synthesis, assignment of absolute stereochemistry, and structural revision of chlorofusin
The first total synthesis of chlorofusin was accomplished in a convergent fashion. With all four unambiguous diastereomeric model… 
2007
2007
Studies toward the synthesis of the Chlorofusin chromophore and development of diazonium ion mimics for organic transformations
2006
2006
Bromoetherification-based strategy towards the spirocyclic chromophore of chlorofusin
A short and direct route to the racemic model chromophore of the potent p53-MDM2 antagonist, chlorofusin, is presented. The… 
2006
2006
Studies towards the synthesis of the p53-MDM2 inhibitor chlorofusin
2006
2006
ORGN 224-Analogs of chlorofusin as potential inhibitors of p53/MDM2 interaction
2004
2004
Using a b-Hairpin To Mimic an a-Helix : Cyclic Peptidomimetic Inhibitors of the p 53 – HDM 2 Protein – Protein Interaction
The design of novel protein ligands and inhibitors of protein– protein interactions is an important goal in post-genomic proteome… 
2003
2003
Towards the total synthesis of chlorofusin: Solid phase synthesis of the cyclic peptide