chloroethylnitrosourea

 
National Institutes of Health

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2008
2008
Protein phosphatase 2A (PP2A), an Akt pathway inhibitor, is considered to be activated by methylation of its catalytic subunit… (More)
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2007
2007
Metabolomics of tumors may allow discovery of tumor biomarkers and metabolic therapeutic targets. Metabolomics by two-dimensional… (More)
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1995
1995
The chloroethylnitrosoureas (CENUs) are important antineoplastic drugs for which clinical utility has been restricted by the… (More)
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1993
1993
A eukaryotic 3-methyladenine DNA glycosylase gene, the Saccharomyces cerevisiae MAG gene, was shown to prevent N-(2-chloroethyl… (More)
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1992
1992
Chloroethylnitrosoureas induce reactive O6-guanine adducts in DNA that can form either interstrand cross-links or a covalent… (More)
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1984
1984
Pulse treatment of DNA with any of several chloroethylnitrosoureas presently in clinical use leads to formation of monoadducts… (More)
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1983
1983
The DNA repair enzyme O6-methylguanine-DNA methyltransferase has been used as a reagent to analyse the initial reaction sites of… (More)
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1983
1983
Chloroethylnitrosoureas (CNU) are antitumor agents which produce DNA interstrand crosslinks. We have proposed that crosslinks are… (More)
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Highly Cited
1980
Highly Cited
1980
The 1-(2-chloroethyl)-1-nitrosoureas are potent anti-cancer drugs1,2 which produce DNA inter-strand cross-links in a two-step… (More)
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1980
1980
Chloroethylnitrosoureas are anticancer agents that undergo chemical reactions in vitro and in vivo to form active alkylating… (More)
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