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chloroethylnitrosourea

 
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Metabolomics of tumors may allow discovery of tumor biomarkers and metabolic therapeutic targets. Metabolomics by two-dimensional… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE A preliminary evaluation of the efficacy of irinotecan in patients with malignant glioma demonstrated modest activity. A… Expand
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1997
1997
Methyl excision repair deficient human tumor cells (Mer-) were found to be hypersusceptible to killing by the antimelanoma agent… Expand
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1995
1995
The chloroethylnitrosoureas (CENUs) are important antineoplastic drugs for which clinical utility has been restricted by the… Expand
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Highly Cited
1992
Highly Cited
1992
Chloroethylnitrosoureas induce reactive O6-guanine adducts in DNA that can form either interstrand cross-links or a covalent… Expand
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Highly Cited
1986
Highly Cited
1986
Human fibroblasts and tumor cells with constitutive levels of the DNA repair protein O6-methylguanine-DNA methyltransferase were… Expand
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Highly Cited
1984
Highly Cited
1984
  • T. Brent
  • Cancer research
  • 1984
  • Corpus ID: 15183626
Pulse treatment of DNA with any of several chloroethylnitrosoureas presently in clinical use leads to formation of monoadducts… Expand
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Highly Cited
1983
Highly Cited
1983
The DNA repair enzyme O6-methylguanine-DNA methyltransferase has been used as a reagent to analyse the initial reaction sites of… Expand
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Highly Cited
1983
Highly Cited
1983
Chloroethylnitrosoureas (CNU) are antitumor agents which produce DNA interstrand crosslinks. We have proposed that crosslinks are… Expand
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Highly Cited
1980
Highly Cited
1980
The 1-(2-chloroethyl)-1-nitrosoureas are potent anti-cancer drugs1,2 which produce DNA inter-strand cross-links in a two-step… Expand
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