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chloroethylnitrosourea

National Institutes of Health

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3 relations
CarmustineLomustine

Broader (1)

Nitrosourea Compounds

Papers overview

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2004
2004
Nitric oxide and BCNU chemoresistance in C6 glioma cells: role of S-nitrosoglutathione.
1997
1997
The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea.
Chloroethylnitrosoureas (CNUs) are being used in the therapy of various neoplastic diseases, including skin cancer. Because… 
Highly Cited
1996
Highly Cited
1996
Human brain tumor O6‐methylguanine‐DNA methyltransferase mRNA and its significance as an indicator of selective chloroethylnitrosourea chemotherapy
O6‐methylguanine‐DNA methyltransferase (MGMT) removes and repairs chloroethylnitrosourea (CENU)‐induced O6‐methylguanine‐DNA by… 
1991
1991
Isolation of two chloroethylnitrosourea-sensitive Chinese hamster cell lines.
1-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-3-(2-chloroethyl)-3- nitrosourea hydrochloride (ACNU), a cancer chemotherapeutic… 
1991
1991
Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines.
Highly Cited
1986
Highly Cited
1986
Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.
Human fibroblasts and tumor cells with constitutive levels of the DNA repair protein O6-methylguanine-DNA methyltransferase were… 
Highly Cited
1984
Highly Cited
1984
Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.
Pulse treatment of DNA with any of several chloroethylnitrosoureas presently in clinical use leads to formation of monoadducts… 
Highly Cited
1983
Highly Cited
1983
Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with…
Chloroethylnitrosoureas (CNU) are antitumor agents which produce DNA interstrand crosslinks. We have proposed that crosslinks are… 
1983
1983
Differential potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine in chloroethylnitrosourea-sensitive and -resistant 9L rat brain tumor cells in vitro.
alpha-Difluoromethylornithine, an enzyme-activated, irreversible inhibitor of ornithine decarboxylase, inhibited the growth of… 
1979
1979
A structure--activity study of seven new water soluble nitrosoureas.
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