FAQ

chemokine (C-X-C motif) ligand 12 signaling pathway

Known as: CXCL12 signaling pathway, SDF1 signaling pathway, stromal cell-derived factor-1 signaling pathway 
A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
0520022018

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C-X-C motif chemokine 12 receptor activity

Related mentions per year

Related mentions per year

1999-2018
1990200020102020
chemokine (C-X-C motif) ligand 12 signaling pathway
C-X-C motif chemokine 12 receptor activity

Papers overview

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2013
2013
Inhibition of CXCL12 signaling attenuates the postischemic immune response and improves functional recovery after stroke.
After stroke, brain inflammation in the ischemic hemisphere hampers brain tissue reorganization and functional recovery. Housing… (More)
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2013
2013
Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.
22q11 deletion syndrome (22q11DS) frequently accompanies psychiatric conditions, some of which are classified as schizophrenia… (More)
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2011
2011
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.
Neutrophils are essential for successful host eradication of bacterial pathogens and for survival to polymicrobial sepsis. During… (More)
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2011
2011
Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.
Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis… (More)
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2011
2011
The preTCR-dependent DN3 to DP transition requires Notch signaling, is improved by CXCL12 signaling and is inhibited by IL-7 signaling.
The requirement for Notch signaling during T-cell development has been extensively studied. Nevertheless, the developmental stage… (More)
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Highly Cited
2010
Highly Cited
2010
Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis.
Multiple sclerosis (MS) is a human demyelinating disease characterized by multifocal regions of inflammation, progressive myelin… (More)
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2010
2010
A pivotal role for CXCL12 signaling in HPV-mediated transformation of keratinocytes: clues to understanding HPV-pathogenesis in WHIM syndrome.
The WHIM syndrome, which features high susceptibility to human papillomavirus (HPV) infection, is a rare immunodeficiency… (More)
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2007
2007
Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease.
INTRODUCTION Atherosclerosis, the underlying disorder of coronary artery disease (CAD), is an inflammatory process involving… (More)
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2005
2005
CXCL12 signaling is independent of Jak2 and Jak3.
Janus kinases (Jaks) are a small family of cytoplasmic tyrosine kinases, critical for signaling by Type I and II cytokine… (More)
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2004
2004
Stromal cell-derived factor (SDF) 1-3'A polymorphism may play a role in resistance to HIV-1 infection in seronegative high-risk Thais.
OBJECTIVE It is known that a 32-bp-deleted CCR5 mutant (CCR5-Delta32) plays a critical role in resistance to human… (More)
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